Results 101 to 110 of about 322,242 (344)

The Reaction of Benzylic Alcohols with Dimethyl Sulfoxide-Polyphosphoric Acid [PDF]

open access: bronze, 1968
Takeo Sato   +4 more
openalex   +1 more source

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

open access: yesAdvanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri   +4 more
wiley   +1 more source

Substrate Engineering for Durable Omniphobic Liquid‐Like Surfaces

open access: yesAdvanced Functional Materials, EarlyView.
The significant yet less investigated role of substrates in determining the liquid‐repellency and mechanical durability of liquid‐like surfaces (LLSs) is explored. Thick and crack‐free sol–gel silica intermediary layers are developed that can smoothen substrate asperity roughness even at the micron scale, enabling omniphobic polydimethylsiloxane‐based ...
Tao Wen   +6 more
wiley   +1 more source

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

open access: yesBiomolecules
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g ...
Kuo-Hao Lee   +3 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang   +9 more
wiley   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

open access: yesAdvanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras   +19 more
wiley   +1 more source

Achieving Stable Paired Electrolysis of Captured CO2 and 5‐Hydroxymethylfurfural (HMF) via Tuning Anolyte Composition and Anode Surface

open access: yesAdvanced Functional Materials, EarlyView.
Highly stable paired electrolysis of CO2 and biomass‐derived alcohol (HMF) is achieved by replacing conventional alkaline electrolytes with a tailored triethylamine‐carbonate buffer and anion‐conducting ionomer coatings. This configuration effectively mitigates electrolyte degradation and pH instability typically encountered in alkaline CO2 ...
Mi‐Young Lee   +3 more
wiley   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

open access: yesAdvanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen   +9 more
wiley   +1 more source

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