Results 21 to 30 of about 264,714 (243)

Thiol-free chemoenzymatic synthesis of β-ketosulfides

Beilstein Journal of Organic Chemistry, 2019
A preparation of β-ketosulfides avoiding the use of thiols is described. The combination of a multicomponent reaction and a lipase-catalysed hydrolysis has been developed in order to obtain high chemical diversity employing a single sulfur donor.
Adrián A. Heredia, Martín G. López-Vidal, Marcela Kurina-Sanz, Fabricio R. Bisogno, Alicia B. Peñéñory   +4 more
doaj   +1 more source

Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors

Molecules, 2017
A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1–3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 ...
Yumei Zhou, Huaqing Cui, Xiaoming Yu, Tao Peng, Gang Wang, Xiaoxue Wen, Yunbo Sun, Shuchen Liu, Shouguo Zhang, Liming Hu, Lin Wang   +10 more
doaj   +1 more source

Ndufaf2, a protein in mitochondrial complex I, interacts in vivo with methionine sulfoxide reductases

Redox Report, 2023
Background Methionine sulfoxide reductases are found in all aerobic organisms. They function in antioxidant defense, cellular regulation by reversible oxidation of methionine in proteins, and in protein structure.
Sujin Park, José A. Trujillo-Hernandez, Rodney L. Levine   +2 more
doaj   +1 more source

Factors associated with variation in single-dose albendazole pharmacokinetics: A systematic review and modelling analysis.

PLoS Neglected Tropical Diseases, 2022
BackgroundAlbendazole is an orally administered anti-parasitic medication with widespread usage in a variety of both programmatic and clinical contexts.
Charles Whittaker, Cédric B Chesnais, Sébastien D S Pion, Joseph Kamgno, Martin Walker, Maria-Gloria Basáñez, Michel Boussinesq   +6 more
doaj   +1 more source

Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice

Saudi Pharmaceutical Journal, 2023
Purpose: The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to gain insight into its pathophysiology and develop potential therapies.
Abdulrazaq Alanazi, Mahmoud N. Nagi, Dhafer Y. Alhareth, Mohammed A Al-Hamamah, Mohamed A Mahmoud, Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Gamaleldin I. Harisa, Sabry M. Attia   +10 more
doaj   +1 more source

Crystal structures of polymerized lithium chloride and dimethyl sulfoxide in the form of {2LiCl·3DMSO}n and {LiCl·DMSO}n

Acta Crystallographica Section E: Crystallographic Communications, 2023
Two novel LiCl·DMSO polymer structures were created by combining dry LiCl salt with dimethyl sulfoxide (DMSO), namely, catena-poly[[chloridolithium(I)]-μ-(dimethyl sulfoxide)-κ2O:O-[chloridolithium(I)]-di-μ-(dimethyl sulfoxide)-κ4O:O], [Li2Cl2(C2H6OS)3]n,
Nichole R. Valdez, David J. Herman, Martin B. Nemer, Mark A. Rodriguez, Eric Allcorn   +4 more
doaj   +1 more source

Sulfoxides

, 2014
Citation: 'sulfoxides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.S06124 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
null Anna, George Wypych
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Design, Synthesis and Preliminary Biological Evaluation of Novel Benzyl Sulfoxide 2-Indolinone Derivatives as Anticancer Agents

Molecules, 2017
In this work, a series of novel benzyl sulfoxide 2-indolinone derivatives was designed and synthesized as potent anticancer agents. Tyrosine kinase inhibitory activity assay indicated that most of the compounds showed significant activity.
Lin Tang, Tao Peng, Gang Wang, Xiaoxue Wen, Yunbo Sun, Shouguo Zhang, Shuchen Liu, Lin Wang   +7 more
doaj   +1 more source

Sulfoxide Reductases and Applications in Biocatalytic Preparation of Chiral Sulfoxides: A Mini-Review

Frontiers in Chemistry, 2021
Chiral sulfoxides are valuable organosulfur compounds that have been widely used in medicinal and organic synthesis. Biocatalytic approaches for preparing chiral sulfoxides were developed in the past few years, mainly through asymmetric oxidation of ...
Tao Peng, Xiaoling Cheng, Yongzheng Chen, Jiawei Yang, Jiawei Yang   +4 more
doaj   +1 more source