Results 51 to 60 of about 434,720 (340)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Active-alkali metal promoted reductive desulfurization of dibenzothiophene and its hindered analogues [PDF]

, 2005
Reductive desulfurisation of organic compounds is of importance both in organic synthesis and in industry. Benzo- and dibenzothiophenes are between the most abundant sulphur containing impurities in crude oils, and their desulfurization is a mandatory ...
Azzena, Ugo Gavino, Carraro, Massimo, Pisano, Luisa, Pittalis, Mario   +3 more
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Deoxydichlorination of aldehydes catalyzed by Diphenyl sulfoxide

Chimica Techno Acta, 2021
The diphenyl sulfoxide-catalyzed conversion of aldehydes to 1,1-dichlorides is reported. The reaction proceeds via a sulfurous (IV)-catalysis manifold in which diphenyl sulfoxide turnover is achieved using oxalyl chloride as a consumable reagent.
I. A. Gorbunova, D. A. Shipilovskikh, S. A. Shipilovskikh   +2 more
doaj   +1 more source

Interaction of methionine sulfoxide reductase B5 with SlMYC2 stimulates the transcription of MeJA-mediated autophagy-related genes in tomato fruit [PDF]

, 2023
Dedong Min, Fujun Li, Maratab Ali, Jiong Liu, Xiaodong Fu, Yanan Song, Jun Ding, Xiaoan Li, Nana Ji, Xinhua Zhang   +9 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

Chemistry
Tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2) are important DNA repair enzymes that remove various adducts from the 3′- and 5′-ends of DNA, respectively.
Aleksandr S. Filimonov, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Irina A. Chernyshova, Tatyana E. Kornienko, Konstantin A. Naumenko, Rashid O. Anarbaev, Andrey A. Nefedov, Chigozie Achara, Anthony D. M. Curtis, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik, Jóhannes Reynisson   +14 more
doaj   +1 more source

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia [PDF]

, 2012
This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH), based on Pluronic® block copolymers, by a new microfluidic approach.
Brognara, Eleonora, Capretto, Lorenzo, Carugo, Dario, Gambari, Roberto, Hill, Martyn, Lampronti, Ilaria, Mazzitelli, Stefania, Nastruzzi, Claudio, Zhang, Xunli   +8 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Synthesis and (spectro)electrochemistry of mixedvalent diferrocenyl–dihydrothiopyran derivatives [PDF]

, 2015
Three novel diferrocenyl complexes were prepared and characterised. 2,2-Diferrocenyl-4,5-dimethyl- 3,6-dihydro-2H-thiopyran (1, sulphide) was accessible by the hetero-Diels–Alder reaction of diferrocenyl thioketone with 2,3-dimethyl-1,3-butadiene ...
Aguirre-Etcheverry, Alexander Hildebrandt, Allen, Barlow, Barrière, Barrière, Becke, Bruno Therrien, Ceccon, Costuas, D'Alessandro, Delgado-Pena, Denifl, Diallo, Diallo, Dominique Miesel, Dong, Dong, Drabowicz, Duggan, Enders, Farrugia, Ferguson, Filipczyk, Fourie, Geiger, Geiger, Gericke, Glover, Gray, Gritzner, Grzegorz Mlostoń, Heinrich Lang, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hush, Inamoto, Jones, Kaleta, Kaleta, Kienz, Konrad Kowalski, Kotz, Kowalski, Kowalski, Krejcik, Lapinte, Larsen, Lee, Lehrich, Linseis, Lohan, Lohan, Miesel, Mücke, Nafady, Nemykin, Nemykin, O'Connor Salazar, Paul, Petrov, Petrov, Pfaff, Pfaff, Pfaff, Pfaff, Pichlmaier, Poppitz, Rafał Czerwieniec, Rafał Karpowicz, Ratner, Ribou, Robin, Rulkens, Sheldrick, Snyder, Speck, Speck, Swarts, Ward, Weeb, Winter, Xie, Xie, Yamaguchi   +87 more
core   +3 more sources