Results 131 to 140 of about 10,355 (182)

Sulfones and Sulfoximines

1977
Sulfones are compounds in which the sulfur atom is bonded to two carbon atoms and two terminal oxygens in a tetrahedral arrangement, which is easily deformable.1 The sulfonyl moiety probably is a hydrid of the forms shown below ...
William E. Truce, Thomas C. Klingler, William W. Brand   +2 more
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N-Trifluoromethylthiolated Sulfoximines

Organic Letters, 2015
Air- and moisture-stable N-trifluoromethylthio sulfoximines have been prepared from N-H-sulfoximines via the corresponding N-Br derivatives in excellent yields. The two-step process starts with an easy-to-perform bromination at the sulfoximine nitrogen, followed by a reaction with silver trifluoromethanethiolate.
Christian, Bohnen, Carsten, Bolm
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Chemosensitization by buthionine sulfoximine in vivo

International Journal of Radiation Oncology*Biology*Physics, 1986
The in vivo effects of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) biosynthesis, on the cytotoxicity of cyclophosphamide (CYM), cisplatin (CDDP) and bleomycin (BLM), were examined by monitoring the changes of non-protein thiols (NPSH) in normal tissues and in the NFSa fibrosarcoma. We used the lung colony assay as a measure of tumor
K, Tsutsui, C, Komuro, K, Ono, T, Nishidai, Y, Shibamoto, M, Takahashi, M, Abe   +6 more
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Amino acid sulfoximines: α-Ethylmethionine sulfoximine

1987
Publisher Summary Several procedures for the synthesis of sulfoximines, also known as “sulfoximides” are reported, amino acid sulfoximines are nearly always synthesized by treatment of the corresponding sulfide or sulfoxide with hydrazoic acid. The procedure does not racemize α-amino acids but does yield an R , S mixture at the suifoximine sulfur;
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A convenient synthesis of vinyl sulfoximines from β-hydroxyalkyl sulfoximines

Tetrahedron Letters, 1987
Abstract Previously unknown free and N-acylated vinyl sulfoximines were readily prepared via elimination of β-hydroxyalkyl methylphenylsulfoximines.
Ki-Jun Hwang, Eugene W. Logusch
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The Preparation of Aliphatic Fluorinated Sulfoximines

Synthesis, 2003
This work describes the preparation of an aliphatic series of the N-trifluoromethanesulfonyl-S-trifluoromethyl-S-sulfoximine group. The key step of the synthesis is the imination of fluorinated sulfoxides under experimental conditions, which avoid cleavage of the alkyl group.
Magnier, Emmanuel, Wakselman, Claude
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Ammonia and methionine sulfoximine intoxication

Brain Research, 1982
Intoxication with ammonium acetate abolished the suppression of action potential generation by cortical postsynaptic inhibition, i.e. produced 'disinhibition', due to the inactivation of neuronal Cl- extrusion. With the occurrence of disinhibition cerebral ammonia increased to 445% of normal; glutamine increased to 170%.
W A, Raabe, G R, Onstad
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Organocatalytic Kinetic Resolution of Sulfoximines

Journal of the American Chemical Society, 2016
An efficient kinetic resolution of sulfoximines with enals was realized using chiral N-heterocyclic carbene (NHC) catalysts. The stereoselective amidation proceeds without additional acyl transfer agent. Both enantiomers of the sulfoximines can be obtained with excellent ee values (up to 99% ee and -97% ee, respectively).
Shunxi, Dong, Marcus, Frings, Hanchao, Cheng, Jian, Wen, Duo, Zhang, Gerhard, Raabe, Carsten, Bolm   +6 more
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Conversion and degradation pathways of sulfoximines

Chemical Society Reviews, 2019
The overview describes laboratory transformations leading to sulfoximine degradations to enable more focussed analyses of potential products and pathways.
Stefan Wiezorek, Philip Lamers, Carsten Bolm   +2 more
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Resolution of diastereomeric sulfoximines

The Journal of Organic Chemistry, 1990
This paper describes a tactic which has provided satisfactory diastereomeric resolution in such a case.
William L. Mock, Joyce Z. Zhang, Chao Zhou Ni, Jon Clardy   +3 more
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