Recent Advances in the Synthesis of Cyclic Sulfoximines via C–H Bond Activation
Molecules, 2023 Sulfoximines, a ubiquitous class of structural motifs, are widely present in bioactive molecules and functional materials that have received considerable attention from modern organic chemistry, pharmaceutical industries, and materials science ...
Qingle Zeng
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Asymmetric synthesis of stereogenic-at-sulfur compounds via biocatalytic oxidation with Unspecific Peroxygenases [PDF]
Nature CommunicationsStereogenic-at-sulfur compounds are vitally important biologically active small molecules, with many drugs featuring chiral sulfur atoms. Methods for the asymmetric synthesis of sulfoxide centres are well established, but methods that produce ...
Jiacheng Li +6 more
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Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors [PDF]
Frontiers in ChemistryIntroductionThe Na–K–2Cl cotransporter isoform 1 (NKCC1) regulates cell volume and ionic distribution, thereby also controlling the efficacy of neuronal GABAergic inhibition. enhanced activity of the NKCC1 chloride importer and high Cl.
Gerald Coste +5 more
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Enzyme-inspired single-molecule photocatalyst enables singlet-oxygen-driven asymmetric epoxidation and sulfoximination [PDF]
Nature CommunicationsThe development of catalytic systems for the enantioselective epoxidation of sterically hindered trisubstituted alkenes using molecular oxygen (O₂) as the terminal oxidant remains a formidable challenge.
Yirui Chen +7 more
doaj +2 more sources
Catalytic Enantioselective Construction of Carbon–Sulfur Bonds: Recent Advances and Future Perspectives [PDF]
MoleculesThe catalytic enantioselective formation of carbon–sulfur (C–S) bonds is a rapidly evolving field in modern organic synthesis, driven by the importance of chiral sulfur-containing motifs in pharmaceuticals, agrochemicals, and functional materials ...
Michał Rachwalski
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Asymmetric S=N-embedded polyaromatic construction via enantioselective Pd-catalyzed C–H activation [PDF]
Nature CommunicationsHeteroatom-doped polyaromatic hydrocarbons show great potential for advancing photoelectric materials. SVI=N doping, characterized by soft-hard atom binding, donor-acceptor transmission, and chiroptical tuning, provides a powerful approach for further ...
Daming Zeng +3 more
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Assembly of (hetero)aryl sulfilimines via copper-catalyzed enantioselective S-arylation of sulfenamides with (hetero)aryl Iodides [PDF]
Nature CommunicationsThe (hetero)aryl sulfoximines are important structures for developing bioactive molecules, whose synthesis relies on oxidation of (hetero)aryl sulfilimines. However, asymmetric approaches for assembling (hetero)aryl sulfilimines are still rare.
Mingchuang He +4 more
doaj +2 more sources
Iron-catalysed stereoselective NH transfer enables dynamic kinetic resolution of sulfoxides [PDF]
Nature CommunicationsTransition metal-catalysed asymmetric nitrene transfer provides a powerful means to access various bioactive N-containing compounds as single enantiomers.
Fang-Xu Fan +4 more
doaj +2 more sources
Rhodium-Catalyzed N‑Allylation of Sulfoximines Using Alkyl Alkynes [PDF]
ACS OmegaJingmin Chen +7 more
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Organocatalytic skeletal reorganization for enantioselective synthesis of S-stereogenic sulfinamides [PDF]
Nature CommunicationsThe enantioselective synthesis of S-stereogenic sulfinamides has garnered considerable attention due to their structural and physicochemical properties.
Zanjiao Liu +6 more
doaj +2 more sources