Results 41 to 50 of about 1,705 (200)

Cu(OAc)₂-Catalyzed N-Arylations of Sulfoximines with Aryl Boronic Acids

, 2016
A simple and mild copper salt-catalyzed N-arylation of sulfoximines in high yields is reported. Cu(OAc)2 activates aryl boronic acids for the reaction with NH-sulfoximines without additional base or heating.
Carsten Bolm (1409422), Christian Moessner (2082376)   +1 more
core   +1 more source

Bridging Chemical Literature and Molecular Graphs: LLM‐Augmented Enantioselectivity Prediction for Iridium‐Catalyzed Asymmetric C–H Borylation

Advanced Science, EarlyView.
A machine‐learning framework for asymmetric C–H borylation bridges multi‐entity 3D molecular graphs and chemical literature. Atom‐resolved mechanistic annotations extracted by large language models augment three‐component graph encoding of catalyst, substrate, and product. The model predicts enantioselectivity with high accuracy on unseen scaffolds and
Zhe Wang, Baohua Zhang, Yi Isaac Yang, Yuan Yao, Yinwu Li   +4 more
wiley   +1 more source

Identification of L-Methionine- S -Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine [PDF]

Proceedings of the National Academy of Sciences, 1970
The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine- S -sulfoximine, inhibits ...
W B, Rowe, A, Meister
openaire   +2 more sources

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Palladium-Catalyzed N-Vinylation of Sulfoximines

, 2016
New previously unavailable N-vinyl sulfoximines have been synthesized by intermolecular palladium-catalyzed coupling between sulfoximines and vinyl bromides in excellent yield.
Carsten Bolm (1409422), Juan R. Dehli (2701303)   +1 more
core   +1 more source

N-(2,3,5,6-Tetrafluoropyridyl)sulfoximines : synthesis, X-ray crystallography, and halogen bonding

, 2020
In the presence of KOH, NH-sulfoximines react with pentafluoropyridine to give N-(tetrafluoropyridyl)sulfoximines (NTFP-sulfoximines) in moderate to excellent yields.
Rissanen, Kari, Rinesch, Torsten, Bolm, Carsten, Puttreddy, Rakesh, Schumacher, Christian, Fergen, Hannah, Truong, Khai-Nghi   +6 more
core   +1 more source

No evidence for negative impacts of acute sulfoxaflor exposure on bee olfactory conditioning or working memory [PDF]

PeerJ, 2019
Systemic insecticides such as neonicotinoids and sulfoximines can be present in the nectar and pollen of treated crops, through which foraging bees can become acutely exposed.
Harry Siviter, Alfie Scott, Grégoire Pasquier, Christopher D. Pull, Mark J.F. Brown, Ellouise Leadbeater   +5 more
doaj   +2 more sources

Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides

Green Synthesis and Catalysis
By virtue of benzothiaselenazole-1-oxides as versatile building blocks and masked sulfoximines, we present a novel and practical trifluoromethylselenolation/fluoroalkylselenolation strategy via Ag(I)-mediated selenium nitrogen exchange (SeNEx) reaction ...
Xinyue Lin, Chensi Li, Zeqin Zhuang, Chongxian Liang, Min Wu, Wei Yi, Zhi Zhou   +6 more
doaj   +1 more source

Sulfur imidations: access to sulfimides and sulfoximines [PDF]

Chemical Society Reviews, 2015
The overview describes sulfur imidation methods providing a practical “tool box” for synthetic chemists and discusses the advantages and disadvantages associated with the use of the various imidating agents.
Bizet, Vincent, Hendriks, Christine M. M., Bolm, Carsten   +2 more
openaire   +3 more sources

The transition metal mediated N-functionalizations of sulfoximines [PDF]

, 2014
This thesis mainly focused on developing dual C-H/N-H oxidative cross-coupling methodologies for the syntheses of N-functionalized sulfoximines from N-H sulfoximines.
Wang, Long
core