Results 1 to 10 of about 328 (86)

The Design, Synthesis and Antiplasmodial Evaluation of Novel Sulfoximine-Isoxazole Hybrids as Potential Antimalarial Agents

European Journal of Medicinal Chemistry Reports
A library of novel sulfoximine-isoxazole hybrids was synthesized and evaluated for antimalarial activity. The subsequential synthetic pathways, which included the alkylation of thiols and simultaneous sulfide oxidation and imination, yielded a library of
Jackie Mabasa, Musawenkosi Nyathi, Paseka T Moshapo   +2 more
exaly   +3 more sources

Sulfoximine Assisted C–H Activation and Annulation via Vinylene Transfer: Access to Unsubstituted Benzothiazines

Molecules, 2023
In this study, we report the synthesis of unsubstituted 1,2-benzothiazines through a redox-neutral Rh(III)-catalyzed C–H activation and [4+2]-annulation of S–aryl sulfoximines with vinylene carbonate.
Koneti Kondalarao, Somratan Sau, Akhila K. Sahoo   +2 more
doaj   +1 more source

A Sublethal Concentration of Sulfoxaflor Has Minimal Impact on Buff-Tailed Bumblebee (Bombus terrestris) Locomotor Behaviour under Aversive Conditioning

Toxics, 2023
Pesticide exposure has been cited as a key threat to insect pollinators. Notably, a diverse range of potential sublethal effects have been reported in bee species, with a particular focus on effects due to exposure to neonicotinoid insecticides.
Laura James, Andrew M. Reynolds, Ian R. Mellor, T. G. Emyr Davies   +3 more
doaj   +1 more source

Transgenerational Effects of a Neonicotinoid and a Novel Sulfoximine Insecticide on the Harlequin Ladybird

Insects, 2021
The harlequin ladybird, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), is a generalist predator and an effective biocontrol agent of various insect pests that has been exploited for the control of aphid pests in the greenhouse and field.
Changchun Dai, Michele Ricupero, Zequn Wang, Nicolas Desneux, Antonio Biondi, Yanhui Lu   +5 more
doaj   +1 more source

Reagent-Controlled Highly Stereoselective Difluoromethylation: Efficient Access to Chiral α-Difluoromethylamines from Ketimines

Molecules, 2022
A reagent-controlled highly stereoselective reaction between (S)-difluoromethyl phenyl sulfoximine 1 and imines is reported, and this synthetic method provides a variety of enantiomerically enriched α-difluoromethyl amines. The main pros of this approach
Qinghe Liu, Taige Kong, Chuanfa Ni, Jinbo Hu   +3 more
doaj   +1 more source

Phenoxazine-Dibenzothiophene Sulfoximine Emitters Featuring Both Thermally Activated Delayed Fluorescence and Aggregation Induced Emission

Molecules, 2021
In this work, we demonstrate dibenzothiophene sulfoximine derivatives as building blocks for constructing emitters featuring both thermally activated delayed fluorescent (TADF) and aggregation-induced emission (AIE) properties, with multiple advantages ...
Yiyu Yang, Ran Xiao, Xiaosong Cao, Zhanxiang Chen, Xialei Lv, Youming Zhang, Shaolong Gong, Yang Zou, Chuluo Yang   +8 more
doaj   +1 more source

Synthesis and Preliminary Screening of the Biological Activity of Sulindac Sulfoximine Derivatives

Applied Sciences, 2023
Sulindac is a well-known anti-inflammatory agent, sometimes employed as an adjuvant in antitumor therapy. Due to the recent interest in sulfoximine for its potential chemotherapeutics, we decided to transform sulindac and its methyl ester into the ...
Cosimo Cardellicchio, Valentino Laquintana, Rosa Maria Iacobazzi, Nunzio Denora, Antonio Scilimati, Maria Grazia Perrone, Maria Annunziata M. Capozzi   +6 more
doaj   +1 more source

Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide–Alkyne Cycloaddition Reactions

Pharmaceuticals, 2023
The recently developed compound, tetramethylthiocycloheptyne sulfoximine (TMTHSI), has shown to be a promising strained alkyne for strain-promoted azide–alkyne cycloaddition (SPAAC), metal-free click chemistry.
Matt Timmers, Andi Kipper, Raphael Frey, Stef Notermans, Maksym Voievudskyi, Claire Wilson, Nina Hentzen, Michael Ringle, Clara Bovino, Bernhard Stump, Cristianne J. F. Rijcken, Tina Vermonden, Ingrid Dijkgraaf, Rob Liskamp   +13 more
doaj   +1 more source

Brugia Malayi: Depletion of Glutathione by Buthionine Sulfoximine [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2005
Glutathione is an intracellular reducing agent. It is synthesized by a two-step reaction catalyzed by ?-glutamylcysteine synthetase (?GCS) and glutathione synthetase.
Ayman Hussein
doaj   +1 more source

In Vivo Effects of Neonicotinoid-Sulfoximine Insecticide Sulfoxaflor on Acetylcholinesterase Activity in the Tissues of Zebrafish (Danio rerio)

Toxics, 2021
Sulfoxaflor is the first member of the neonicotinoid-sulfoximine insecticides that acts as an agonist of nicotinic acetylcholine receptors (nAChRs).
Petek Piner Benli, Mehmet Çelik
doaj   +1 more source