Ammonium assimilation inhibitors weaken the growth of moso bamboo seedlings through metabolic dysregulation [PDF]
PeerJBackground The uncontrolled expansion of moso bamboo (Phyllostachys edulis) in subtropical regions threatens forest ecosystem integrity and biodiversity, yet effective control measures are lacking.
Ziye Li +6 more
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Sulfoximine N -Functionalization with N -Fluorobenzenesulfonamide [PDF]
The Journal of Organic ChemistryAn operationally simple, convenient, mild, metal-free, and scalable transformation of sulfoximines with N-fluorobenzenesulfonamide is presented. A wide range of structurally different NH-sulfoximines were prepared and reacted with N-fluorobenzenesulfonamide in the presence of TMP (2,2,6,6-Tetramethylpiperidine) and in the environmentally friendly EtOAc
Žan Testen +2 more
openaire +5 more sources
Responses of Anti-Apoptotic Molecules to EAgNPs and EAgNPs Plus L-Buthionine-Sulfoximine in Human Tongue Cancer Cells [PDF]
MoleculesSilver nanoparticles (AgNPs) have emerged as a promising nanoplatform for oncological intervention, yet their clinical translation is severely hampered by systemic toxicities associated with high effective doses, while the underlying mechanisms governing
Ximing Wu +6 more
doaj +2 more sources
Mechanism of l-Buthionine-(S,R)-sulfoximine-induced ferroptotic cell death in mouse hippocampal neuronal cells [PDF]
Cell Communication and SignalingRecent studies have revealed that accumulation of cellular nitric oxide (NO) resulting from protein disulfide isomerase (PDI)-catalyzed dimerization (i.e., catalytic activation) of nitric oxide synthase (NOS) is a pivotal upstream event in the induction ...
Yiru Wang, Xiangyu Hao, Bao Ting Zhu
doaj +2 more sources
Molecules, 2019 Novel anthranilic diamides with sulfilimidoyl and sulfoximidoyl functionalities were successfully prepared. Among newly-prepared organosulfur compounds, 3-bromo-1-(3-chloropyridin-2-yl)-N-(2-methyl-6-(methylcarbamoyl)-4-(methylthio)phenyl)-1H-pyrazole-5 ...
Hwan Jung Lim +2 more
doaj +1 more source
Synthesis and Transformations of NH‐Sulfoximines [PDF]
Chemistry – A European Journal, 2021 Abstract Recent years have seen a marked increase in the occurrence of sulfoximines in the chemical sciences, often presented as valuable motifs for medicinal chemistry. This has been prompted by both pioneering works taking sulfoximine containing compounds into clinical trials and the concurrent development of powerful synthetic ...
Michael Andresini +4 more
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Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction
SynOpen, 2022 The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C in the presence of InCl3.
C. P. Irfana Jesin +2 more
doaj +1 more source
3-bromopyruvate and buthionine sulfoximine effectively kill anoikis-resistant hepatocellular carcinoma cells. [PDF]
PLoS ONE, 2017 Acquisition of anoikis resistance is a prerequisite for metastasis in hepatocellular carcinoma (HCC). However, little is known about how energy metabolism and antioxidant systems are altered in anoikis-resistant (AR) HCC cells.
Minjong Lee +12 more
doaj +1 more source
Antioxidants, 2020 Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism, also ...
Adriana Cruz +8 more
doaj +1 more source
A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
Communications Chemistry, 2022 Platinum(IV) complexes have the potential to overcome several limitations and reduce adverse effects of platinum-based cancer therapy. Resistance to clinically approved platinum(II) drugs is, at least in part, associated with elevated levels of ...
Philipp Fronik +9 more
doaj +1 more source