Results 31 to 40 of about 10,355 (182)
Тонкие химические технологии, 2021 Objectives. This study aims to obtain the amino acid derivatives of chlorophyll a and bacteriochlorophyll a for the targeted delivery of pigments to tumor foci. This will increase biocompatibility and, as a result, reduce toxic side effects.
A. F. Mironov +7 more
doaj +1 more source
Identification of L-Methionine- S -Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine [PDF]
Proceedings of the National Academy of Sciences, 1970 The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine- S -sulfoximine, inhibits ...
W B, Rowe, A, Meister
openaire +2 more sources
Biologia Plantarum, 2015 In this study, proteome and activities of glutathione (GSH)-related enzymes were investigated in detached leaves of Arabidopsis thaliana treated with ochratoxin A (OTA) alone or supplemented with buthionine sulfoximine (BSO, a specific inhibitor of the ...
J. R. Hao +8 more
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Photoinduced acylations of sulfoximines and transformations of an N-phthalimidoyl sulfoximine
, 2022 Published by RWTH Aachen University ...
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In vitro suppression of inflammatory cytokine response by methionine sulfoximine
Journal of Inflammation, 2018 Background The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peritoneal macrophages triggered with ...
Tyler J. Peters +2 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The glutamine synthetase expression system is widely used for therapeutic protein biomanufacturing in Chinese hamster ovary (CHO) cells. Here, we present the design of an enhanced glutamine synthetase vector for generating CHOK1SV GS‐KO stable pools that produce recombinant proteins at multigram‐per‐liter levels. We first developed a synthetic
Yusuf B. Johari +11 more
wiley +1 more source
Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly
Bulletin of the Korean Chemical Society, EarlyView.Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim +7 more
wiley +1 more source
Sulfur imidations: access to sulfimides and sulfoximines [PDF]
Chemical Society Reviews, 2015 The overview describes sulfur imidation methods providing a practical “tool box” for synthetic chemists and discusses the advantages and disadvantages associated with the use of the various imidating agents.
Bizet, Vincent +2 more
openaire +3 more sources
C─S Bond Formation of Aryl Germanes
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Site‐selective C─S bond formation of aryl germanes, even in the presences of other functional groups such as silane or boron derivatives, is described. The protocol operates under metal‐free conditions at room temperature without the need of inert atmosphere.
Jaime Ponce‐de‐León +6 more
wiley +2 more sources
l-Buthionine Sulfoximine Detection and Quantification in Polyurea Dendrimer Nanoformulations
Molecules, 2019 l-Buthionine sulfoximine (l-BSO) is an adjuvant drug that is reported to increase the sensitivity of cancer cells to neoplastic agents. Dendrimers are exceptional drug delivery systems and l-BSO nanoformulations are envisaged as potential ...
Pedro Mota +3 more
doaj +1 more source