Results 51 to 60 of about 10,355 (182)

Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and γ-Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum

Frontiers in Cellular Neuroscience, 2019
Glutathione (GSH) is the most abundant intracellular antioxidant. GSH depletion leads to oxidative stress and neuronal damage in the central nervous system (CNS).
Cesar Valdovinos-Flores, Jorge H. Limón-Pacheco, Renato León-Rodríguez, Pavel Petrosyan, Carla Garza-Lombó, Maria E. Gonsebatt   +5 more
doaj   +1 more source

PKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damage. [PDF]

PLoS ONE, 2011
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous ...
Barbara Marengo, Chiara De Ciucis, Roberta Ricciarelli, Mario Passalacqua, Mariapaola Nitti, Jean-Marc Zingg, Umberto M Marinari, Maria A Pronzato, Cinzia Domenicotti   +8 more
doaj   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

Thiolane Sulfoximines as Azide Surrogates for Quinolyl Nitrenes: Photochemical Access to Ortho‐Diaminoquinolines

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Thiolane sulfoximines provide practical and safer surrogates for hazardous azides in nitrene photochemistry, enabling direct access to 7,8‐diaminoquinolines and fused δ‐lactams. DFT calculations support the reaction mechanism and rationalize product selectivity.
Lorenzo Serusi, Timothé Maujean, Camille Van Wesemael, Romain Pertschi, Vicenç Branchadell, Mihaela Gulea   +5 more
wiley   +1 more source

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, Volume 13, Issue 63, 12 November 2026.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

ReactELISA method for quantifying methylglyoxal levels in plasma and cell cultures

Redox Biology, 2019
Methylglyoxal (MG) is a toxic glycolytic by-product associated with increased levels of inflammation and oxidative stress and has been linked to ageing-related diseases, such as diabetes and Alzheimer's disease.
Rasmus Kold-Christensen, Karina Kragh Jensen, Emil Smedegård-Holmquist, Lambert Kristiansen Sørensen, Jakob Hansen, Karl Anker Jørgensen, Peter Kristensen, Mogens Johannsen   +7 more
doaj   +1 more source

Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

Cancer Cell International, 2005
Background Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet, though glutathione (GSH) is ...
Savas Burhan, Akca Hakan, Akan Selma, Akan Ilhan, Ozben Tomris   +4 more
doaj   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +1 more source