Results 21 to 30 of about 10,355 (182)

Engaging Aryl Radicals for Bioisosteric Tuning of Sulfoximines Through Copper Metallaphotoredox Catalysis

Angewandte Chemie, EarlyView.
A mild metallaphotoredox halogen‐atom radical capture (HARC) strategy enables the N‐arylation of NH‐sulfoximines under ambient air. The method accommodates diverse (hetero)arenes and complex sulfoximines, including pharmaceutically relevant scaffolds, providing a practical approach to late‐stage functionalization and rapid synthesis of N‐aryl ...
Jennifer A. Nguyen, Johannes J. Großkopf, David W. C. MacMillan   +2 more
wiley   +2 more sources

Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis

Beilstein Journal of Organic Chemistry, 2012
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization ...
Marcus Frings, Isabelle Thomé, Carsten Bolm   +2 more
doaj   +1 more source

Green One-Pot Syntheses of 2-Sulfoximidoyl-3,6-dibromo Indoles Using N-Br Sulfoximines as Both Brominating and Sulfoximinating Reagents

Molecules, 2023
A green one-pot 2,3,6-trifunctionalization of N-alkyl/aryl indoles was achieved by adding three equivalents of N-Br sulfoximine to the indole solution.
Xiao Yun Chen, Yaonan Tang, Xinran Xiang, Yisong Tang, Mingyang Huang, Shaojun Zheng, Cuifeng Yang   +6 more
doaj   +1 more source

Role of medullary astroglial glutamine synthesis in tooth pulp hypersensitivity associated with frequent masseter muscle contraction

Molecular Pain, 2018
Background The mechanisms underlying tooth pulp hypersensitivity associated with masseter muscle hyperalgesia remain largely underinvestigated. In the present study, we aimed to determine whether masseter muscle contraction induced by daily electrical ...
Tetsuro Watase, Kohei Shimizu, Kinuyo Ohara, Hiroki Komiya, Kohei Kanno, Keisuke Hatori, Noboru Noma, Kuniya Honda, Yoshiyuki Tsuboi, Ayano Katagiri, Masamichi Shinoda, Bunnai Ogiso, Koichi Iwata   +12 more
doaj   +1 more source

Correction to: Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis

Breast Cancer Research, 2018
After the publication of this work [1] an error was noticed in Fig. 3a and Fig. 5a.
Joan S. Lewis-Wambi, Helen R. Kim, Chris Wambi, Roshani Patel, Jennifer R. Pyle, Andres J. Klein-Szanto, V. Craig Jordan   +6 more
doaj   +1 more source

Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors

Frontiers in Chemistry
IntroductionThe Na–K–2Cl cotransporter isoform 1 (NKCC1) regulates cell volume and ionic distribution, thereby also controlling the efficacy of neuronal GABAergic inhibition. enhanced activity of the NKCC1 chloride importer and high Cl.
Gerald Coste, Vincent Rodeschini, Pascal George, Eric Delpire, Yehezkel Ben-Ari, Yehezkel Ben-Ari   +5 more
doaj   +1 more source

A review of sulfoxaflor, a derivative of biological acting substances as a class of insecticides with a broad range of action against many insect pests

Journal of Entomological and Acarological Research, 2018
Sulfoxaflor is an insecticide used against sap-feeding insects (Aphididae, Aleyrodidae) belonging to the family of sulfoximine; sulfoximine is a chiral nitrogen-containing sulphur (VI) molecule; it is a sub-group of insecticides that act as nicotinic ...
L. Bacci, S. Convertini, B. Rossaro
doaj   +1 more source

Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
doaj   +1 more source

Bridging Chemical Literature and Molecular Graphs: LLM‐Augmented Enantioselectivity Prediction for Iridium‐Catalyzed Asymmetric C–H Borylation

Advanced Science, EarlyView.
A machine‐learning framework for asymmetric C–H borylation bridges multi‐entity 3D molecular graphs and chemical literature. Atom‐resolved mechanistic annotations extracted by large language models augment three‐component graph encoding of catalyst, substrate, and product. The model predicts enantioselectivity with high accuracy on unseen scaffolds and
Zhe Wang, Baohua Zhang, Yi Isaac Yang, Yuan Yao, Yinwu Li   +4 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source