Resurrected nitrogenases recapitulate canonical N-isotope biosignatures over two billion years. [PDF]
Rucker HR +6 more
europepmc +1 more source
ABSTRACT Background Hydrogen sulfide (H2S) is an endogenous gasotransmitter regulating redox balance, inflammation, and vascular tone, but reproducing the spatial and kinetic features of endogenous production remains challenging. We examine sulfurous thermal waters as natural contexts of sustained H2S exposure, using the Saturnia springs (Tuscany ...
Elisabetta Ferrara +6 more
wiley +1 more source
Understanding Mass Spectrometry: From Ion Generation to Spectral Interpretation
ABSTRACT This tutorial provides a structured introduction to mass spectrometry (MS), with particular emphasis on electrospray ionization (ESI)–based measurements. It is intended to support researchers from chemistry and related disciplines in developing a coherent understanding of MS principles, instrumentation, and data interpretation.
Arnold Steckel +2 more
wiley +1 more source
An integrated framework to identify and characterize regional-scale insect dispersal. [PDF]
Dargent F +9 more
europepmc +1 more source
ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley +1 more source
Redox Dynamics of the Atmosphere and Oceans Induced by the Paleoproterozoic Snowball Earth Events. [PDF]
Harada M, Miura Y, Watanabe Y, Ozaki K.
europepmc +1 more source
Centennial‐scale phosphorus accumulation drives regeneration and internal loading in a boreal lake
Abstract Legacy anthropogenic phosphorus (P) accumulated in sediments drives internal P loading in eutrophic lakes. However, predicting the temporal response of internal P loading to the external loading reduction is difficult due to the complexity of sedimentary P cycling. In this study, we use geochemical profiles obtained from a 180‐cm sediment core
Siqi Zhao +5 more
wiley +1 more source
Metabolic Regulation of Macrophages in Health and Disease
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
Coupling Liquid Chromatography to Orbitrap Isotope Ratio Mass Spectrometry: Overcoming Isotope Effects of Chromatography and Amount-Dependency by Peak Homogenization. [PDF]
Canavan A +5 more
europepmc +1 more source
Nucleotide Metabolism in Health and Disease
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
wiley +1 more source

