Results 71 to 80 of about 12,154 (204)

Inhibition studies of Brucella suis β-carbonic anhydrases with a series of 4-substituted pyridine-3-sulphonamides

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The two β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Brucella suis, BsuCA1 and BsuCA2, were investigated for their inhibition profile with a series of pyridine-3-sulphonamide derivatives incorporating 4-hetaryl moieties.
Simona Maria Monti, Angela Meccariello, Mariangela Ceruso, Krzysztof Szafrański, Jarosław Sławiński, Claudiu T. Supuran   +5 more
doaj   +1 more source

The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures

Journal of Enzyme Inhibition and Medicinal Chemistry
In the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo[4,3-e ...
Anna Szymanowska, Dominika Radomska, Robert Czarnomysy, Mariusz Mojzych, Katarzyna Kotwica-Mojzych, Krzysztof Bielawski, Anna Bielawska   +6 more
doaj   +1 more source

Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type PhX (X = COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding derivatives with sulphur(VI)-based ZBGs (X = SO3H, SO2NH2, SO2NHNH2, SO2NHOH, SO2NHOMe) were ...
Claudiu T. Supuran
doaj   +1 more source

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitory ...
Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Claudia Melis, Benedetta Fois, Andrea Angeli, Clemente Capasso, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni   +13 more
doaj   +1 more source

Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides.
Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz, Claudiu T. Supuran   +7 more
doaj   +1 more source

Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities.
David Izuchukwu Ugwu, Uchechukwu Christopher Okoro, Pius Onyeoziri Ukoha, Astha Gupta, Sunday N. Okafor   +4 more
doaj   +1 more source

Oxidation of para-methoxy benzaldehyde and salicylaldehyde by N-sodio-N-chlorotoluene sulphonamide (chloramine-T) in acid medium: A kinetic and mechanistic study

, 2001
The kinetics of oxidation of para-methoxy benzaldehyde and salicylaldehyde by chloramine-T (CAT) have been investigated in hydrochloric acid medium at 303 K. The rate shows first order dependence on CAT] and fractional order in aldehyde].
Veerabhadraswamy, M., Rangaswamy, Venkatachalapathy, R.   +2 more
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Effect of antimicrobials administered via liquid feed on the occurrence of sulphonamide and trimethoprim resistant Enterobacteriaceae: case-control study

Porcine Health Management, 2017
Background Drugs for the treatment of groups of pigs receiving liquid feed are frequently mixed into the feed and administered via the pipelines of the feeding installations.
Oliver Heller, Roger Stephan, Sophie Thanner, Michael Hässig, Giuseppe Bee, Andreas Gutzwiller, Xaver Sidler   +6 more
doaj   +1 more source

Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione, para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity

E-Journal of Chemistry, 2005
1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation with p –amino acetophenone gives 1-[acetyl] -
Rakesh N. Mistry, K. R. Desai
doaj   +1 more source

Synthesis of some sulphonamide insect juvenile hormone - Part I

, 2008
1291-1297Regular use of classical insecticides has drastically effected the environment and warm blooded animals. Therefore, there is an urgent need to look for a kind of chemicals which are very specific, targeted in their action and environment ...
Awasthi, Pamita, Mahajan, R K
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