Results 121 to 130 of about 175,802,720 (255)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Summary of best evidence for identification and management of acquired dysphagia in critically ill patients

Huli yanjiu
ObjectiveTo summarize the evidence related to the identification and management of acquired dysphagia in critically ill patients.MethodsUsing evidence⁃based nursing methods， literature was searched based on the "6S" model.
XUE Xiujuan, QIAO Jianhong, QIN Guangya, MA Xinlu, XIA Xiaomei, WANG Yeqing   +5 more
doaj  

Executive Summary of Evidence and Consensus-Based Clinical Practice Guidelines for Management of Obesity and Overweight in Midlife Women: An AIIMS-DST Initiative. [PDF]

J Midlife Health, 2022
Ranjan P, Vikram NK, Choranur A, Pradeep Y, Ahuja M, Meeta M, Puri M, Malhotra A, Kumari A, Chopra S, Batra A, Balsalkar G, Goswami D, Guleria K, Sarkar S, Kachhawa G, Verma A, Kumari MK, Madan J, Dabral A, Kamath S, Rathore AM, Kumar R, Venkataraman S, Kaloiya G, Bhatla N, Kumari SS, Baitha U, Prakash A, Tiwaskar M, Tewary K, Misra A, Guleria R.   +32 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COVID-19 Health Evidence Summary No.23

, 2020
This daily COVID-19 Health Evidence Summary is to signpost DFID and other UK government departments to the latest relevant evidence and discourse on COVID-19 to inform and support their response.
Kerry Millington (210010)
core   +1 more source

ESCAP practice guidance for autism: a summary of evidence-based recommendations for diagnosis and treatment. [PDF]

Eur Child Adolesc Psychiatry, 2021
Fuentes J, Hervás A, Howlin P, (ESCAP ASD Working Party).   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Best Evidence Summary for Improving Self-Awareness of Falls in Elderly Postoperative Patients with Osteoporotic Vertebral Compression Fracture

Journal of Multidisciplinary Healthcare
Yujia Huo,1 Xiaohong Wang,2 Yu Wang,3 Jianing Yang,3 Yuqi Zeng,1 Hongxia Du21School of Nursing, Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China; 2Department of Nursing, Central Hospital Affiliated to Shandong ...
Huo Y, Wang X, Wang Y, Yang J, Zeng Y, Du H   +5 more
doaj  

Diagnosis and Management of Uncomplicated Chlamydia trachomatis Infections in Adolescents and Adults: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines. [PDF]

Clin Infect Dis, 2022
Geisler WM, Hocking JS, Darville T, Batteiger BE, Brunham RC.   +4 more
europepmc   +1 more source