Results 91 to 100 of about 46,190 (264)
The FEBS Journal, EarlyView.Insoluble protein aggregates are a hallmark of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). The ubiquitin–proteasome system (UPS) serves as a neuroprotective quality control mechanism that clears aggregates. PML nuclear bodies (NBs) were proposed to serve as hubs for SUMO‐primed ubiquitylation and degradation of misfolded ...
Tabea Stark, Stefan Müller
wiley +1 more source
Cellular Physiology and Biochemistry, 2017 Background: It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo.
Lifang Jin +4 more
doaj +1 more source
New Phytologist, EarlyView.Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth +5 more
wiley +1 more source
New Phytologist, EarlyView.Proposed regulatory model of OsMYB305 in leaf senescence. Summary Accumulating evidence has identified transcription factors (TFs) as key regulators of the onset and progression of leaf senescence. However, the regulatory role of the rice myeloblastosis (MYB) TF OsMYB305 in this process remains largely unknown.
Boyeong Kim +7 more
wiley +1 more source
Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases
, 2022 SUMOylation is a post-translational modification that has emerged in recent decades as a mechanism involved in controlling diverse physiological processes and that is essential in vertebrates.
Jafari, Vahid +5 more
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Molecular Oral Microbiology, EarlyView.Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin +6 more
wiley +1 more source
SUMO chain formation is required for response to replication arrest in S. pombe.
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
doaj +1 more source
MYB Factors: Hubs of Plant Stress and Hormone Crosstalk
Plant Biotechnology Journal, EarlyView.ABSTRACT MYB transcription factors function as main regulatory hubs that integrate environmental signals with multi‐hormonal pathways to synchronize plant growth, metabolism and stress responses. This review delineates the regulatory roles of MYB in the signalling pathway of salicylic acid, jasmonic acid, ethylene and abscisic acid signalling.
Aye Aye Htun +9 more
wiley +1 more source
Planta, 2004 Covalent attachment of small proteins to substrates can regulate protein activity in eukaryotes. SUMO, the small ubiquitin-related modifier, can be covalently linked to a broad spectrum of substrates. An understanding of SUMO's role in plant biology is still in its infancy.
Novatchkova, M. +4 more
openaire +4 more sources