Results 81 to 90 of about 46,190 (264)
Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
The FEBS Journal, EarlyView.PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Production and Purification of SUMO-UBC9 and SUMO-RANGAP1CTD
SUMOylation is a post-translational modification catalyzed by a multi-step enzymatic cascade. To gain structural biology insights into the last step of this process, where SUMO is transferred from a SUMO~UBC9 molecule onto a substrate, stable complexes with SUMO covalently linked to UBC9, the substrate, or both are essential.
Cisse, El Hadji +3 more
openaire +3 more sources
, 2012 SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
core
SUMO control of nervous system development
, 2023 In the last decades, the post-translational modification system by covalent attachment of the SUMO polypeptide to proteins has emerged as an essential mechanism controlling virtually all the physiological processes in the eukaryotic cell.
García-Gutiérrez, Pablo +1 more
core +1 more source
Textile waste management and recycling opportunities and challenges for Africa: a mini-review [PDF]
The Holistic Approach to EnvironmentGlobal fibre supply increased to 113 million tonnes in 2021, contributing to elevated energy and water consumption levels, agricultural pollution, and post-consumer textile waste.
Peter Davis Sumo
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, EarlyView.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
The FEBS Journal, EarlyView.Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet +6 more
wiley +1 more source
, 2019 <p>This is the most contributers to a release so far!</p> <ul> <li><p>Bug fixes</p> <ul> <li>Fix error in P monoclinic (<em>b</em>-unique) "Bradcrack" high-symmetry path (C. N. Savory)</li>
Adam J. Jackson +7 more
core +1 more source
, 2021 Post-translational modification by covalent attachment of the Small ubiquitin-like modifier (Sumo) polypeptide regulates a multitude of processes in vertebrates.
Barysch, Sina V. +5 more
core +1 more source
Global SUMO proteome responses guide gene regulation, mRNA biogenesis, and plant stress responses
Frontiers in Plant Science, 2012 Small-ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on ...
Magdalena eMazur +1 more
doaj +1 more source