Results 71 to 80 of about 299,473 (288)

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]

PLoS ONE, 2017
BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk, Melanie C Audette, Sascha Drewlo, Khrystyna Levytska, John C Kingdom   +4 more
doaj   +1 more source

Time-domain parametric sensitivity analysis of multiconductor transmission lines [PDF]

, 2011
We present a new parametric macromodeling technique for lossy and dispersive multiconductor transmission lines (MTLs). This technique can handle design parameters, such as substrate or geometrical layout features, and provide time-domain sensitivity ...
Antonini, G, Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc, Spina, Domenico   +4 more
core   +2 more sources

SUMO Chains Rule on Chromatin Occupancy

Frontiers in Cell and Developmental Biology, 2020
The dynamic and reversible post-translational modification of proteins and protein complexes with the ubiquitin-related SUMO modifier regulates a wide variety of nuclear functions, such as transcription, replication and DNA repair.
Jan Keiten-Schmitz, Kathrin Schunck, S. Müller   +2 more
semanticscholar   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

MULTI-OBJECTIVE OPTIMIZATION OF TRAFFIC SIGNAL TIMINGS FOR MINIMIZING WAITING TIME, CO2 EMISSIONS, AND FUEL CONSUMPTION AT INTERSECTIONS

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
In this paper, we present an optimization strategy that uses Genetic Algorithms (GA) to reduce Waiting Time, CO2 Emissions, and fuel consumption in a transportation network.
Esraa Alkafaji, Husham L. Swadi
doaj   +1 more source

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Primary host defenses against viruses involve specific cellular recognition of non-self nucleic acids as pathogen-associated molecular patterns (PAMPs) that trigger induction of cytokine-mediated antiviral responses.
Nora Schmidt, P. Domingues, F. Golebiowski, Corinna Patzina, M. Tatham, R. Hay, B. G. Hale   +6 more
semanticscholar   +1 more source

SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression

Genes & Cancer, 2010
Small ubiquitin-like modifiers (SUMO) conjugation to cellular proteins is a reversible posttranslational modification that mediates the protein's function, subcellular localization, and/or expression. The SUMO proteases (SENP) deconjugate modified proteins and thus are critical for maintaining the level of SUMOylated and un-SUMOylated substrates ...
Tasneem, Bawa-Khalfe, Edward T H, Yeh
openaire   +3 more sources

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations

Cell Reports, 2023
Summary: The small ubiquitin-like modifier (SUMO) protease SENP6 disassembles SUMO chains from cellular substrate proteins. We use a proteomic method to identify putative SENP6 substrates based on increased apparent molecular weight after SENP6 depletion.
Magda Liczmanska, Michael H. Tatham, Barbara Mojsa, Ania Eugui-Anta, Alejandro Rojas-Fernandez, Adel F.M. Ibrahim, Ronald T. Hay   +6 more
doaj   +1 more source

SUMO conjugation – a mechanistic view

Biomolecular Concepts, 2017
The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways.
A. Pichler, C. Fatouros, Heekyoung Lee, N. Eisenhardt   +3 more
semanticscholar   +1 more source