Results 51 to 60 of about 46,190 (264)
Advanced Science, EarlyView.ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch +4 more
wiley +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. [PDF]
PLoS ONE, 2009 SUMO is a protein modifier that is vital for multicellular development. Here we present the first system-wide analysis, combining multiple approaches, to correlate the sumoylated proteome (SUMO-ome) in a multicellular organism with the developmental ...
Minghua Nie +3 more
doaj +1 more source
Advanced Science, EarlyView.Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo +4 more
wiley +1 more source
Development of a Middleware between SUMO simulation tool and JaCaMo framework
Advances in Distributed Computing and Artificial Intelligence Journal, 2018 Smart City has an infrastructure that works with technology to reduce daily problems. The lack of parking spots is one of these problems that can be controlled by creating Smart Parking systems.
Alexis van HAARE HEIJMEIJER +1 more
doaj +1 more source
SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]
PLoS ONE, 2017 BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk +4 more
doaj +1 more source
A Photo-Crosslinking Approach to Identify Class II SUMO-1 Binders
Frontiers in Chemistry, 2022 The small ubiquitin-like modifier (SUMO) is involved in various cellular processes and mediates known non-covalent protein-protein interactions by three distinct binding surfaces, whose interactions are termed class I to class III.
Kira Brüninghoff +4 more
doaj +1 more source
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
, 2016 SUMO Region = SR; S = SUMO-acceptor site (red = mutated in this study, black = potential SUMO-acceptor sites [23, 35–37]; LAM = La Motif; RRM = RNA Recognition Motif; NRE = Nuclear Retention Element; RCD = RNA Chaperone Domain; NoLS = Nucleolar ...
Jeffery L. Twiss (149555) +6 more
core +1 more source
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗIn this paper, we present an optimization strategy that uses Genetic Algorithms (GA) to reduce Waiting Time, CO2 Emissions, and fuel consumption in a transportation network.
Esraa Alkafaji, Husham L. Swadi
doaj +1 more source