Results 121 to 130 of about 29,696 (227)

A Critical Analysis of the Impact of Etoposide as a Topoisomerase II Inhibitor in Cervical Cancer Treatment: A Review

Cancer Medicine, Volume 15, Issue 3, March 2026.
Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Nikitha Kotian, Yashaswini Reddy, Padmini Pai, Babitha Kampa Sundara   +3 more
wiley   +1 more source

NGHIÊN CỨU VỀ UPPER ONTOLOGY TRỰC TUYẾN

Tạp chí Khoa học Đại học Cần Thơ, 2015
Chúng tôi trình bày cách tiếp cận mới về ánh xạ giữa WordNet và SUMO (Suggested Upper Merged Ontology) cũng như công cụ trình duyệt SUMO trực tuyến có thể sử dụng để duyệt SUMO, và sự kết nối của nó với từ vựng WordNet.
Huỳnh Nhứt Phát, Hoàng Hữu Hạnh, Phan Công Vinh   +2 more
doaj  

Lone‐Pair Shielded Radicals: Beyond the Captodative Substitution Pattern

ChemistryEurope, Volume 4, Issue 3, March 2026.
Lone‐pair shielded radical! This work demonstrates the generality of the lone‐pair shielding effect, where a lone‐pair‐like orbital (red) shields the radical‐electron orbital (green) associated with the electron pair bond. The effect weakens the C–C bond as substituents become less electronegative, offering a useful handle for tuning bond strengths. We
Steven E. Beutick, Maarten J. H. van Dorp, Trevor A. Hamlin, J. Martijn van der Schuur, Daniela Rodrigues Silva, F. Matthias Bickelhaupt   +5 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

SUMOylation is destined for regulatory T cell-related immune dysregulation. [PDF]

Cell Death Discov
Qian J, Yu L, Tian M, Li X, Bai X, Yang J, Deng R, Liu Q, Lyu A, Xiao C, Liu Y.   +10 more
europepmc   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus. [PDF]

J Cell Biol
Rogers AM, Broussard BK, Taylor R, Egan MJ.   +3 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Tandem solubility enhancing tags enable the heterologous expression and <i>in vitro</i> maturation of a class IIa bacteriocin, clesteriocin a, identified in <i>Candidatus Clostridium mucoides</i> CM038. [PDF]

Front Microbiol
Wambui J, Tasara T, Bigler L, Stephan R.
europepmc   +1 more source

Induced opening of conformational switch I in GTP‐bound Ran GTPase

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Ran is a small GTPase that regulates nucleocytoplasmic transport by cycling between an inactive GDP‐bound and active GTP‐bound state. Structurally, Ran consists of a globular G‐domain and a C‐terminal region that includes a C‐terminal helix. The switch I and II regions of the G‐domain undergo major conformational changes upon GTP hydrolysis ...
Janka Czigleczki, Balint Dudas, Erika Balog   +2 more
wiley   +1 more source