Results 11 to 20 of about 299,473 (288)
Identification of proximal SUMO-dependent interactors using SUMO-ID [PDF]
Nature Communications, 2020 The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family pose significant challenges for research. Here we present SUMO-ID, a technology that merges proximity biotinylation by TurboID and protein-fragment ...
Orhi Barroso-Gomila +15 more
semanticscholar +7 more sources
SUMO targeting of a stress-tolerant Ulp1 SUMO protease. [PDF]
PLoS ONE, 2018 SUMO proteases of the SENP/Ulp family are master regulators of both sumoylation and desumoylation and regulate SUMO homeostasis in eukaryotic cells. SUMO conjugates rapidly increase in response to cellular stress, including nutrient starvation, hypoxia ...
Jennifer Peek +8 more
doaj +4 more sources
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. [PDF]
Nature Communications, 2017 Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
Ahmad, Alla S +8 more
core +3 more sources
Journal of Medicinal Chemistry, 2021 SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of
S. Langston +52 more
semanticscholar +1 more source
SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
T. Yau +3 more
semanticscholar +1 more source
Cell Reports, 2021 In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins.
R. González-Prieto +8 more
semanticscholar +1 more source
EMBO Journal, 2021 DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasome but can ...
Julio C Y Liu +15 more
semanticscholar +1 more source
SUMO is a pervasive regulator of meiosis
eLife, 2021 Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified.
Nikhil R Bhagwat +12 more
semanticscholar +1 more source
Therapeutic Potential of Targeting the SUMO Pathway in Cancer
Cancers, 2021 Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer.
Antti Kukkula +5 more
semanticscholar +1 more source