EXAMINING THE SAFETY IMPACTS OF TRANSIT PRIORITY SIGNAL SYSTEMS USING SIMULATION TECHNIQUES [PDF]
Transit Priority Signal (TPS) systems are increasingly used to improve traffic efficiency and reduce passenger waiting times. However, such systems may carry potential safety risks.
Erdem
doaj +1 more source
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço +21 more
core +1 more source
Adherens junctions (AJs) play a crucial role in epithelial tissue development and tumorigenesis, and the mechanisms controlling their assembly and disassembly have therefore attracted considerable attention. A paper from Tsur et al. (2015) in this issue of Developmental Cell now shows how sumoylation and desumoylation of E-cadherin promotes its ...
openaire +3 more sources
A role for SUMO modification in transcriptional repression and activation [PDF]
Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
Lyst, M J, Stancheva, I
core +1 more source
Improving AODV Performance by Software Defined Networking Using NS3
Nowadays, vehicular networks attract car manufacturers, network researchers, and governments as well. They represent one of the building blocks, for the intelligent transportation systems.
Brahmia Hanene +2 more
doaj +1 more source
Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]
The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Seifert, Anne +3 more
core +1 more source
An adaptive real-time grey-box model for advanced control and operations in WRRFs
Grey-box models, which combine the explanatory power of first-principle models with the ability to detect subtle patterns from data, are gaining increasing attention in wastewater sectors.
Cheng Yang +3 more
doaj +1 more source
Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3 [PDF]
SUMOylation is a reversible process regulated by a family of sentrin/SUMO-specific proteases (SENPs). Of the six SENP family members, except for SENP1 and SENP2, the substrate specificities of the rest of SENPs are not well defined. Here, we have described SENP5, which has restricted substrate specificity.
Limin, Gong, Edward T H, Yeh
openaire +2 more sources
SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço +24 more
core +1 more source
Small ubiquitin-like modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin [PDF]
Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins.
Bennett, M. +33 more
core +1 more source

