Results 1 to 10 of about 5,360 (128)

Ubc9‐mediated SUMOylation of Ninj1 alleviates inflammatory responses in hepatic ischaemia/reperfusion injury [PDF]

Clinical and Translational Medicine
Background Hepatic ischaemia/reperfusion (I/R) injury poses a common clinical dilemma encountered during liver transplantation (LT), characterised by substantial cellular death and inflammation reactions.
Kang Huang, Li Xu, Shufang Na, Yan Xu, Qiaoyun Liu, Shaojun Ye, Cong‐Yi Wang, Wei Zhou, Qifa Ye   +8 more
doaj   +3 more sources

Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice [PDF]

Biomedicines
Objective: SUMOylation is a crucial protein modification that regulates various physiological and pathological processes. Ubc9 serves as a key ubiquitin-conjugating enzyme in the process of SUMOylation.
Peng Lv, Wenchao Xu, Bin Yang, Dengjianyi Xu, Tao Wang, Jihong Liu, Xiaming Liu   +6 more
doaj   +2 more sources

UBC9-mediated regulation of K144 ubiquitination of Lamin A and its implications for hepatocellular carcinoma [PDF]

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. UBC9, the sole E2 conjugating enzyme in the SUMOylation pathway, is frequently overexpressed in HCC, yet its specific role in hepatocarcinogenesis remains ...
QingShui Wang, Ziqiang Liao, Hao Zhang, Ziyi Jin, Zhuoqin Zhong, Xinji Gao, YiMin Huang, Menghua Qiu, Wudan Ren, Yunjia Liu, Liyan Zhang, Runjing Fan, Yaqian Feng, Kunmu Zhang, Yehuda G. Assaraf, Yao Lin   +15 more
doaj   +2 more sources

UBC9-mediated SUMOylation of CORO1C drives lung adenocarcinoma progression via Arp2/3-dependent cytoskeletal remodeling [PDF]

Cell Death and Disease
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide, and understanding its molecular drivers is critical for improving therapeutic outcomes.
Zhe Zhang, Bing Xiao, Yupeng Jiang, Lixia Niu, Li Wang, Juan Cai   +5 more
doaj   +2 more sources

microRNA-214-mediated UBC9 expression in glioma [PDF]

BMB Reports, 2012
It has been reported that ubiquitin-conjugating enzyme 9 (Ubc9),the unique enzyme2 in the sumoylation pathway, is up-regulatedin many cancers. However, the expression and regulation ofUBC9 in glioma remains unknown.
Xiaochao Tan, Xiaozhong Peng, Boqin Qiang   +2 more
exaly   +1 more source

Curcumin attenuates α-synuclein pathology in Parkinson’s disease model mice through modulation of UBC9-associated SUMOylation signaling [PDF]

Frontiers in Neuroscience
BackgroundPost-translational modifications, particularly SUMOylation, plays a crucial role in α-synuclein (α-syn) aggregation, a key pathological feature of Parkinson’s disease (PD).
Yao Li, Zhuang Zhu, Kezhong Zhang
doaj   +2 more sources

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis [PDF]

Advanced Science
Although Ubc9‐mediated SUMOylation are recognized to regulate the multiple aspects of hepatic biological processes, its impact on hepatic senescence and metabolic dysfunction‐associated steatotic liver disease (MASLD), however, is yet to be fully ...
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
doaj   +2 more sources

UBC9 overexpression promotes proliferation and metastasis in gastric cancer via ATF2 [PDF]

World Journal of Surgical Oncology
Gastric cancer remains a leading cause of cancer-related mortality worldwide, characterized by poor prognosis due to its aggressive nature and high metastatic potential.
QingShui Wang, ShengZhao Li, YiNing Xu, Yuluo Chen, Chao Xu, QiuYan He, Yan Ye, YiMin Huang, Yue Wu, KeJia Guo, YaJuan Wei, Yide Huang, Yan Liu, Qing Lin, Shanshan Wang, Feng Li, Minghan Huang, FangQin Xue, Yao Lin   +18 more
doaj   +2 more sources

m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]

Cellular and Molecular Life Sciences
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang   +5 more
doaj   +2 more sources

SUMOylation involved in malignant progression of multiple tumors and SENP5 may improve the chemotherapy sensitivity of hypoxic tumors [PDF]

Frontiers in Pharmacology
IntroductionSmall ubiquitin-related modifier (SUMO), a ubiquitin-like modification protein, is implicated in the aggressive progression of various tumor types.
Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Bing Han, Bing Han, Yanxia Li, Yanxia Li, Yuxiang Wang, Yuxiang Wang, Min Liu, Zhongmin Jiang, Wenhan Wu, Wenhan Wu, Xiaozhi Liu, Xiaozhi Liu, Xiaozhi Liu, Yafei Liu, Mingyong Liu, Mingyong Liu, Mingyong Liu   +20 more
doaj   +2 more sources