Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
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Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways. [PDF]
PLoS ONE, 2010 Canonical ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo, NEDD8, and ISG15 are ligated to targets by E1-E2-E3 multienzyme cascades. The Sumo cascade, conserved among all eukaryotes, regulates numerous biological processes including protein ...
Jing Wang +7 more
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Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.
PLoS Pathogens, 2017 UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of essential cellular functions and, as such, is frequently altered in cancers. Along these lines, we recently reported that its expression gradually increases during early
Domenico Mattoscio +14 more
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Observation of an E2 (Ubc9)-homodimer by crystallography [PDF]
Data in Brief, 2016 Post-translational modifications by the small ubiquitin-like modifiers (SUMO), in particular the formation of poly-SUMO-2 and -3 chains, regulates essential cellular functions and its aberration leads to life-threatening diseases (Geoffroy and Hay, 2009)
Aileen Y. Alontaga +8 more
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Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
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Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage. [PDF]
PLoS ONE, 2011 We have previously shown that a massive increase in global SUMOylation occurs during torpor in ground squirrels, and that overexpression of Ubc9 and/or SUMO-1 in cell lines and cortical neurons protects against oxygen and glucose deprivation.
Yang-Ja Lee +5 more
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Elevated UBC9 expression and its oncogenic role in colorectal cancer progression and chemoresistance
Scientific ReportsColorectal cancer (CRC) is a highly prevalent and fatal malignancy, with incidence and mortality rates rising globally. While elevated UBC9 expression has been implicated in various cancers, its specific role in CRC remains poorly understood.
Feng Li +9 more
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Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway. [PDF]
PLoS ONE, 2017 UBC9, the only known E2-conjugating enzyme involved in SUMOylation, is a key regulator in fibrosis. However, the roles of UBC9 in liver fibrosis remain unclear.
Sufen Fang +6 more
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Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux
Frontiers in Pharmacology, 2020 AimsSUMOylation is a post-translational modification that plays a crucial role in the cellular stress response. We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury.Methods and ...
Qing Xiao +18 more
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The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer
Frontiers in Molecular Biosciences, 2022 Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to ...
Maria Elisa Sabatini +11 more
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