Estrogen receptor alpha and nuclear factor Y coordinately regulate the transcription of the SUMO-conjugating UBC9 gene in MCF-7 breast cancer cells. [PDF]
PLoS ONE, 2013 UBC9 encodes a protein that conjugates small ubiquitin-related modifier (SUMO) to target proteins thereby changing their functions. Recently, it was noted that UBC9 expression and activity play a role in breast tumorigenesis and response to anticancer ...
Shibo Ying +3 more
doaj +1 more source
Channels, 2022 The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target.
Jiahe Li +4 more
doaj +1 more source
Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein. [PDF]
PLoS ONE, 2017 SUMOylation is a reversible post-translational modification that regulates the function of target protein. In this study, we first predicted by software that the multiple proteins of porcine reproductive and respiratory syndrome virus (PRRSV) could be ...
Cong Wang +8 more
doaj +1 more source
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]
Open Biology, 2017 Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa +11 more
doaj +1 more source
Cell Death and Disease, 2023 SUMOylation is an evolutionary conserved regulatory mechanism, in which Ubc9 is the only E2 conjugating enzyme. Previous studies demonstrated that SUMOylation is involved in multiple biological processes, but its role in dendritic cells (DCs) remains to ...
Jing Zhang +13 more
doaj +1 more source
Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner. [PDF]
PLoS ONE, 2013 The cellular E2 Sumo conjugase, Ubc9 interacts with HIV-1 Gag, and is important for the assembly of infectious HIV-1 virions. In the previous study we demonstrated that in the absence of Ubc9, a defect in virion assembly was associated with decreased ...
Christopher R Bohl +2 more
doaj +1 more source
Knockdown of Ubc9 induces Relish nuclear translocation and AMP expression.
, 2021 (A) Knockdown of Ubc9 produces melanotic tumors in larvae. Ubc9 was knocked down or over-expressed via Act5Cts. Melanotic tumors, as arrows indicate, were observed near the posterior end of Ubc9 knockdown larvae but not the control and Ubc9 over ...
Wuren Huang (3493211) +5 more
core +1 more source
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
doaj +1 more source
Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks [PDF]
, 2006 SummaryThe Ubc9 SUMO-conjugating enzyme and the Siz1 SUMO ligase sumoylate several repair and recombination proteins, including PCNA. Sumoylated PCNA binds Srs2, a helicase counteracting certain recombination events. Here we show that ubc9 mutants depend
T. Enomoto +17 more
core +1 more source
TRAF3 SUMOylation is Ubc9-dependent.
, 2013 (A) Over-expression of “dominant-negative” Ubc9C93A which is unable to catalyze formation of SUMO conjugates reduces endogenous TRAF3 SUMOylation. HEK293 cells were transfected with Ubc9C93A and lysates were obtained using an IDO-containing lysis buffer.
Aristides G. Eliopoulos (486506) +3 more
core +1 more source