Results 41 to 50 of about 6,573 (167)

Ubc9 fusion-directed sumoylation (UFDS) of Tec1.

, 2013
A, whole cell lysates from tec1Δ cells transformed with plasmids that express triple-FLAG-tagged Tec1, a Tec1-Ubc9 fusion, a Tec1K54R-Ubc9 fusion, or the parent vector were immunoprecipitated with M2 anti-FLAG resin and subjected to immunoblotting using ...
Yuqi Wang (270190), Mihretu Ayalew (369951), Kristina Suntay (369952), Ameair Abu Irqeba (281061)   +3 more
core   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

Expression level of Ubc9 protein in rat tissues. [PDF]

, 2003
Ubc9 is a homologue of the E2 ubiquitin conjugating enzyme and participates in the covalent linking of SUMO-1 molecule to the target protein. In this report we describe a simple and efficient method for obtaining pure human recombinant Ubc9 protein.
Szulc, Aneta, Sakowicz, Monika, Pawełczyk, Tadeusz, Gołębiowski, Filip, Szutowicz, Andrzej   +4 more
core  

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

SUMOylation‐Dependent Repression of BIRC7 by DNMT3a Suppresses Papillary Thyroid Carcinoma Progression

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy, and while most patients respond well to standard therapies, a subset displays aggressive behavior, including lymph node metastasis and recurrence. The molecular mechanisms underlying PTC progression remain incompletely understood.
Kunpeng Liu, Zijie Su, Hongguang Li
wiley   +1 more source

Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae

, 2013
Posttranslational modification with the small ubiquitin-related modifier SUMO depends on the sequential activities of E1, E2, and E3 enzymes. While regulation by E3 ligases and SUMO proteases is well understood, current knowledge of E2 regulation is very
Pichler, A., Xaver, M., Xaver, Martin, Klug, H., Klug, Helene, Chaugule, V., Mittler, G., Klein, Franz, Koidl, S., Chaugule, Viduth K., Klein, F., Pichler, Andrea, Koidl, Stefanie, Mittler, Gerhard   +13 more
core   +1 more source

Regulation Of Nuclear Localization Of The Sole Sumo-Conjugating Enzyme, Ubc9 [PDF]

, 2013
The covalent and reversible conjugation of small ubiquitin-like modifier (SUMO) proteins to hundreds of different cellular proteins is catalyzed by a cascade of enzymes including an E1-activating enzyme (SAE1/SAE2), an E2-conjugating enzyme (Ubc9) and ...
Sekhri, Palak
core   +1 more source

E2 Ubiquitin-Conjugating Enzymes Regulates Dengue Virus-2 Replication in Aedes albopictus

Microorganisms
Aedes albopictus, a major vector of dengue virus (DENV), has a global distribution. Identifying the key components of the ubiquitin system of A. albopictus essential for the replication of viruses could help identify targets for developing broad-spectrum
Jiaqi Wang, Xueli Zheng, Xuexue Wang, Daibin Zhong, Guofa Zhou   +4 more
doaj   +1 more source

The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression. [PDF]

PLoS ONE, 2011
PR-Set7/Set8/KMT5a is a chromatin-modifying enzyme that specifically monomethylates lysine 20 of histone H4 (H4K20me1). In this study we attempted to identify PR-Set7-interacting proteins reasoning that these proteins would provide important insights ...
Tanya M Spektor, Lauren M Congdon, Chendhore S Veerappan, Judd C Rice   +3 more
doaj   +1 more source

Organ‐on‐a‐Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration

Smart Medicine, Volume 5, Issue 4, August 2026.
Organ‐on‐a‐chip to miniaturize the human intervertebral disc in modeling key degenerative features, including ECM degradation, inflammation, neovascularization, sensory innervation, and nociception toward precision translation for studying disease mechanisms and therapeutic testing.
Izzat Zulkiflee, Nurul Fariha Za'aba, Abhay Pandit, Isma Liza Mohd Isa   +3 more
wiley   +1 more source