Results 61 to 70 of about 6,573 (167)

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

UBC9 directly binds the N-terminal region of PR-Set7.

, 2013
(A) The indicated recombinant fusion proteins were expressed in E. coli, purified by affinity chromatography and fractionated by SDS-PAGE.
Judd C. Rice (178101), Tanya M. Spektor (347013), Lauren M. Congdon (347014), Chendhore S. Veerappan (347015)   +3 more
core   +1 more source

ITSN1 binds the E2-conjugating enzyme UBC9

Фактори експериментальної еволюції організмів
Aim. Scaffolding protein of the intersectin 1 (ITSN1) associated with malignant cell transformation. A short isoform of ITSN1 (ITSN1-S) can localize to the nucleus and inhibit breast cancer cell proliferation but the exact mechanisms of ITSN1 nuclear ...
K. O. Kozyrieva, T. A. Gryaznova
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

A mechanistic view of the role of E3 in sumoylation.

PLoS Computational Biology, 2010
Sumoylation, the covalent attachment of SUMO (Small Ubiquitin-Like Modifier) to proteins, differs from other Ubl (Ubiquitin-like) pathways. In sumoylation, E2 ligase Ubc9 can function without E3 enzymes, albeit with lower reaction efficiency.
Melda Tozluoğlu, Ezgi Karaca, Ruth Nussinov, Türkan Haliloğlu   +3 more
doaj   +1 more source

Shared and distinct roles of Esc2 and Mms21 in suppressing genome rearrangements and regulating intracellular sumoylation.

PLoS ONE, 2021
Protein sumoylation, especially when catalyzed by the Mms21 SUMO E3 ligase, plays a major role in suppressing duplication-mediated gross chromosomal rearrangements (dGCRs). How Mms21 targets its substrates in the cell is insufficiently understood.
Raymond T Suhandynata, Yong-Qi Gao, Ann L Zhou, Yusheng Yang, Pang-Che Wang, Huilin Zhou   +5 more
doaj   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

SUMOylation In Cerebral Ischaemia: A Dynamic, Isoform‐Specific Regulator of Neuroprotection and Injury

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Ischaemic stress has been demonstrated to induce a robust increase in SUMOylation, thereby promoting adaptive mechanisms that regulate protein relocalisation, stabilisation, degradation, and activation. Following hypoxic–ischaemic insult, both SUMO‐1 and SUMO‐2/3 conjugation increase, although the temporal dynamics and subcellular distribution of these
João M. Gissoni, Kiara F. Campos, Helena L. A. Vieira, Carlos Alexandre Netto, Luz Elena Durán‐Carabali, Helena I. Cimarosti   +5 more
wiley   +1 more source

UBC9 silencing-mediated PPARa deSUMOylation induces inhibition of cell proliferation by ferroptosis in acute myeloid leukemia

Archives of Medical Science
Introduction Inhibited acute myeloid leukemia (AML) proliferation is accompanied by downregulated peroxisome proliferator-activated receptor a (PPARa), which however can be stabilized via SUMOylation. This study investigated how PPARa SUMOylation impacts
Xiaolu Song, Fangfang Shi, Xiaogang Wang, Ye Peng, Huafang Wang, Lai Jin, Jianping Lan   +6 more
doaj   +1 more source

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage

Journal of Experimental & Clinical Cancer Research, 2019
Background Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components.
Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi, Ning Gao   +9 more
doaj   +1 more source