Results 81 to 90 of about 6,573 (167)
Human Ubc9 Contributes to Production of Fully Infectious Human Immunodeficiency Virus Type 1 Virions [PDF]
, 2009 Ubc9 was identified as a cellular protein that interacts with the Gag protein of Mason-Pfizer monkey virus. We show here that Ubc9 also interacts with the human immunodeficiency virus type 1 (HIV-1) Gag protein and that their interaction is important for
West, John T., Jr. +11 more
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MHC Class I Antigen Presentation is Regulated by the SUMO-Conjugating Enzyme UBC9: a Dissertation
, 2006 Some images did not scan well. Please consult original document.CD8 T cells recognize complexes of MHC class I and peptide on the surface of target cells.
Shen, Yuelei
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Stability of gp160 is unchanged in Ubc9 knockdown cells.
, 2013 (a) 293T cells were transfected with pNL4-3 MUT 511 alone, or in combination with Ctr. siRNA or Ubc9 siRNA, or left untransfected. Cells were pulse (P) labeled with [35S] methionine/cysteine for 1 hour, then chased for 2 and 4 hours.
Charles Wood (33830) +2 more
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SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced ScienceRetinal vasculopathies pose a devastating threat to human health. While anti‐VEGF therapy situates the first‐line treatment for patients, the clinical efficacy is limited by suboptimal response and potential risks raised by long‐term high‐dosage use ...
Zheng Zhong +9 more
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Cancer Biology & TherapyDouble minutes (DMs), extrachromosomal gene fragments found within certain tumors, have been noted to carry onco- and drug resistance genes contributing to tumor pathogenesis and progression.
Yusi Wang +15 more
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Nature CommunicationsThe human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.
Vladimir Baytshtok +2 more
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Identification of a substrate recognition site on Ubc9.
, 2002 Human Ubc9 is homologous to ubiquitin-conjugating enzymes. However, instead of conjugating ubiquitin, it conjugates a ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), also known as UBL1, GMP1, SMTP3, PIC1, and sentrin.
Tatham, HM +7 more
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UBC9 preferentially promotes SUMO1 conjugation ex vivo.
, 2017 (A) and (B) Left: Representative IHC images of FFPE human normal, LSIL or HSIL cervical tissues stained with anti-SUMO1 or anti-SUMO2/3 antibodies, respectively.
Claudia Miccolo (377902) +14 more
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Nature CommunicationsThe peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells
Qiuhong Zhu +16 more
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The Role Of Ubc9 In Drug Resistance And Its Expression Regulation In Cancer Cells
, 2009 As a posttranslational modification, the sumoylation pathway plays a key role in a wide variety of cellular events such as cell proliferation, differentiation, stress response, DNA repair and apoptosis. Given the important role of protein sumoylation, it
Wu, Fangting
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