Results 101 to 110 of about 6,573 (167)

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

, 2017
SUMOylation is an important posttranslational modification that regulates protein function in diverse biological processes. However, its role in early T cell development has not been genetically studied. UBC9 is the only E2 enzyme for all SUMOylation. In
Deng Pan, Xin, Huawei, Wei Jin, Bo Zhong, Xindong Liu, Chen Dong, Liu, Xindong, Dejean, Anne, Ding, Xiao, Zhong, Bo, Jin, Wei, Maud Demarque, Dong, Chen, Demarque, Maud, Wang, Aibo, Pan, Deng, Huawei Xin, Xiao Ding, Anne Dejean, Aibo Wang, Wang, Xiaohu, Xiaohu Wang   +21 more
core   +1 more source

Model of autophagic-mediated UBC9 degradation and its impairment by HPV16 E6/E7 in HKs.

, 2017
(A) In normal conditions, UBC9 protein expression is retained at physiological levels by basal autophagy in HKs. (B) However, the presence of HPV16 E6/E7 impairs autophagosome-autolysosome fusion.
Claudia Miccolo (377902), Massimo Tommasino (8382), Chiara Casadio (3808876), Carlo Tacchetti (252415), Marta Tagliabue (3808885), Fausto Chiesa (3808888), Fausto Maffini (3808870), Michael Pawlita (77239), Susanna Chiocca (119134), Domenico Mattoscio (3808882), Tarik Gheit (348201), Francesca De Lorenzi (3808867), Mohssen Ansarin (3808873), Andrea Raimondi (749423), Viviana E. Galimberti (3808879)   +14 more
core   +1 more source

ChemLTP upregulates of SUMO-1 and Ubc9 protein levels.

, 2013
A) ChemLTP increases in SUMO-1 and Ubc9 immunoreactivity with no change in the intensity of SUMO-2 staining. Mean fluorescence intensity was analysed using ImageJ. Graphs show quantification of 3 independent experiments, 10 neurons per condition (ANOVA. *
Sriharsha Kantamneni (289400), Philip Rubin (289401), Tim J. Craig (289403), Filip A. Konopacki (289398), Thomas F. Owen (289399), Kevin A. Wilkinson (289405), Nadia Jaafari (289396), Jeremy M. Henley (289407)   +7 more
core   +1 more source

Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation

, 2010
Importin13 (Imp13) is an unusual beta-karyopherin that is able to both import and export cargoes in and out of the nucleus. In the cytoplasm, Imp13 associates with different cargoes such as Mago-Y14 and Ubc9, and facilitates their import into the nucleus
Grunwald, M., Marlene Grünwald, Fulvia Bono, Bono, F.   +3 more
core   +1 more source

ChemLTP increases SUMO-1 and Ubc9 mRNA.

, 2013
A) Fluorescent in situ hybridization using cRNA probes for SUMO-1, SUMO-2 and Ubc9 (red) in hippocampal neurons co-stained with the dendritic marker MAP-2 (green).
Sriharsha Kantamneni (289400), Philip Rubin (289401), Tim J. Craig (289403), Filip A. Konopacki (289398), Thomas F. Owen (289399), Kevin A. Wilkinson (289405), Nadia Jaafari (289396), Jeremy M. Henley (289407)   +7 more
core   +1 more source

Ubiquitin‐conjugating enzyme E2 for regulating autophagy in diabetic cardiomyopathy: A mini‐review

Journal of Diabetes
The prevalence of diabetic cardiomyopathy (DCM) increases year by year with the increase in the prevalence of diabetes mellitus (DM), which is one of the most serious cardiovascular complications of DM and a major cause of death in diabetic patients ...
Yueran Zhou, Zequn Zheng, Shenglin Wu, Jinxiu Zhu   +3 more
doaj   +1 more source

UBC9 and PI3K Expression in Colorectal Cancer: Possible Prognostic Role. [PDF]

APMIS
Nasser O, Rabea A, Diaa R.
europepmc   +1 more source

Characterization of the down-regulation of SUMO E2 Ubc9 by cholesterol-dependent cytolysins

, 2017
Ph.D.Cholesterol-dependent cytolysins (CDCs) belong to one of the families of pore-forming toxins that highly associated with bacterial pathogenesis. Membrane disruption of the infected cells is thought to be the major function of CDCs.

core  

PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization. [PDF]

J Exp Med
Wu HC, Laplantine E, Esnault C, Niwa-Kawakita M, Zhang Y, De Almeida Bastos V, Geoffroy MC, de Thé H.   +7 more
europepmc   +1 more source

Single-Nucleotide Polymorphism (SNP) c.73G>A in the UBC9 (E2) SUMO Gene and Breast Cancer Risk in Polish Women. [PDF]

Cancers (Basel)
Romanowicz H, Sychowski G, Kalinowski S, Sypniewski S, Zakharin O, Zadrożny M, Łukasiewicz H, Samulak D, Smolarz B.   +8 more
europepmc   +1 more source