Results 71 to 80 of about 6,573 (167)
Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity
Advanced Science, Volume 13, Issue 21, 13 April 2026.This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou +8 more
wiley +1 more source
Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang +3 more
wiley +1 more source
Insect Science, Volume 33, Issue 2, Page 517-532, April 2026.Abstract The Sterile Insect Technique (SIT) is an environmentally friendly, sustainable pest control approach, which uses large‐scale releases of sterile insects to suppress or eradicate target populations through infertile matings. The efficiency of SIT is enhanced by male‐only releases requiring genetic sexing strains (GSSs) that are classically ...
Chun Yin Leung +2 more
wiley +1 more source
Developmental regulation of Ubc9 in the rat nervous system [PDF]
, 2008 The SUMO-conjugating enzyme Ubc9 is an essential enzyme in the SUMO (small ubiquitin-related modifier) protein modification system. Although sumoylation, covalent modification of cellular proteins by SUMO, is considered to regulate various cellular ...
Takahashi, Hiroshi +4 more
core
PLoS ONE, 2013 Multiple pathways participate in the AMPA receptor trafficking that underlies long-term potentiation (LTP) of synaptic transmission. Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient ...
Nadia Jaafari +7 more
doaj +1 more source
Role of UBC9 in the regulation of the adipogenic program in 3T3-L1 adipocytes
, 2010 The small ubiquitin-like modifier-conjugating enzyme UBC9, involved in protein modification through covalent attachment of small ubiquitin-like modifier and other less defined mechanisms, has emerged as a key regulator of cell proliferation and ...
CIGNARELLI, ANGELO +9 more
core +2 more sources
, 2003 The small ubiquitin-like modifier SUMO-1 is covalently attached to lysine residues on target proteins by a specific conjugation pathway involving the E1 enzyme SAE1/SAE2 and the E2 enzyme Ubc9. In an ATP-dependent manner, the C-tern-tinus of SUMO-I forms
Hay, Ronald Thomas, Chen, Y, Tatham, MH
core +1 more source
Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis
Journal of Experimental & Clinical Cancer Research, 2019 Background The Slug-E-cadherin axis plays a critical role in non-small-cell lung cancers (NSCLCs) where aberrant upregulation of Slug promotes cancer metastasis.
Pei-Fang Hung +11 more
doaj +1 more source
FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells
, 2018 Forkhead Box Protein P3 (FOXP3), a transcription factor of the FOX protein family, is essentially involved in the development of regulatory T (Treg) cells, and functions as a tumor suppressor.
Lizhong Wang +4 more
core +1 more source
Channels, 2018 Drug discovery campaigns directly targeting the voltage-gated sodium channel NaV1.7, a highly prized target in chronic pain, have not yet been clinically successful.
Liberty François-Moutal +5 more
doaj +1 more source