Results 231 to 240 of about 291,935 (374)

Identification and functional analysis of ULP2 SUMO protease mutants of the stress-tolerant yeast <i>Kluyveromyces marxianus</i>. [PDF]

MicroPubl Biol
Hutson C, Li S, Sweeney K, Kerscher O.
europepmc   +1 more source

O sumo padre re celestiale

Xu Cbe Ibumanira, Dela Fua Intrata
openalex   +2 more sources

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science, Volume 12, Issue 39, October 20, 2025.
ASP aggravates TEC injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive Drp1 SUMOylation in DKD mice. However, either ASP deficiency or AASP effectively alleviates the kidney injury and mitochondrial dynamics disorder induced by STZ/HFD, highlighting that ASP could be an early diagnostic marker and potential ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
wiley   +1 more source

Ovarian SUMO-2/3 targets and their differential response to genotoxic stress induced by 7,12-dimethylbenz(a) anthracene exposure in lean and obese female mice†. [PDF]

Biol Reprod
Rishi JK, Montes C, Walley JW, Keating AF.   +3 more
europepmc   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, Volume 12, Issue 40, October 27, 2025.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

SUMOylation balance: a key determinant in synapse physiology. [PDF]

Front Physiol
Bertozzi A, Toscanelli W, Castellitto G, Grassi C, Colussi C.   +4 more
europepmc   +1 more source

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

, 2000
Yong Mao, Mei Sun, Shyamal D. Desai, Leroy F. Liu   +3 more
openalex   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote. [PDF]

Sci Adv
Banda J, Ghosh S, Roy D, Ingole KD, Clark L, Sharma E, Kakkunath S, Sue-Ob K, Bhosale R, Band L, Ghosh S, Wells D, Atkinson J, Provart NJ, Bennett MJ, Lilley KS, Jones A, De Lucas M, Bishopp A, Sadanandom A.   +19 more
europepmc   +1 more source

Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study introduces two orthogonal sequencing methods, CMD1‐Deaminase sequencing (CD‐seq) and CMD1‐TET bisulfite sequencing (CT‐seq), that enable direct, independent detection of 5mC. Using these approaches together with ACE‐seq or TAB‐seq for 5hmC identification, the study reveals a significant reduction in 5hmC, but not 5mC, in the hippocampus of ...
Zi‐Xin Wang, Faying Chen, Bao‐Dan He, Fan‐Chen Wang, Jiaxue Cha, Yu Song, Wei‐Ying Meng, Wan‐Yue Zou, Yu‐Tao Fu, Shu‐Xia Sun, Zhi‐Yan Sun, Hao‐Ming Jiang, Ke‐Yao Zhao, Yujun Hou, Jiejun Shi, Jian‐Huang Xue   +15 more
wiley   +1 more source