Results 271 to 280 of about 291,935 (374)

Coupling Modelling and Fault Propagation Simulation Method for Power Grid‐Centric Urban Lifeline Systems Under Extreme Disasters

open access: yesEnergy Internet, Volume 2, Issue 3, Page 255-273, October 2025.
ABSTRACT The interconnection of urban critical infrastructure poses new challenges to the secure operation of power grid‐centric urban lifeline systems. The interdependencies among infrastructure systems increase the risk of cascading fault propagation, thereby threatening urban public safety.
Chengeng Zhang   +3 more
wiley   +1 more source

TRIM28 is a target for paramyxovirus V proteins. [PDF]

open access: yesPLoS Pathog
Lieber G   +4 more
europepmc   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 20, Page 4876-4893, October 2025.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

SUMOylation of ZEB1 Modulates PANoptosis in Burn‐Induced Early Acute Kidney Injury

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Burn‐induced acute kidney injury (AKI) involves inflammatory programmed cell death pathways, including PANoptosis. This study investigated how SUMOylation of the transcription factor ZEB1 regulates PANoptosis in early burn‐induced AKI. Human AKI datasets were analyzed for ZEB1 expression and correlation with PANoptosis/SUMOylation genes. A rat
Juncheng Zhang   +6 more
wiley   +1 more source

SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly. [PDF]

open access: yesGenes Dev
He S   +10 more
europepmc   +1 more source

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