A Method for SUMO Modification of Proteins in vitro
Bio-Protocol, 2018 The Small Ubiquitin-related Modifier (SUMO) is a protein that is post-translationally added to and reversibly removed from other proteins in eukaryotic cells.
Christine Lee +3 more
doaj +4 more sources
Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9 [PDF]
Journal of Biological Chemistry, 2001 Conjugation of the small ubiquitin-like modifier SUMO-1/SMT3C/Sentrin-1 to proteins in vitro is dependent on a heterodimeric E1 (SAE1/SAE2) and an E2 (Ubc9). Although SUMO-2/SMT3A/Sentrin-3 and SUMO-3/SMT3B/Sentrin-2 share 50% sequence identity with SUMO-1, they are functionally distinct.
Michael H. Tatham +6 more
openalex +5 more sources
SUMO-SIM interactions regulate the activity of RGSZ2 proteins. [PDF]
PLoS ONE, 2011 The RGSZ2 gene, a regulator of G protein signaling, has been implicated in cognition, Alzheimer's disease, panic disorder, schizophrenia and several human cancers.
Javier Garzón +6 more
doaj +6 more sources
Phototropin Interactions with SUMO Proteins [PDF]
Plant and Cell Physiology, 2021 Abstract The disruption of the sumoylation pathway affects processes controlled by the two phototropins (phots) of Arabidopsis thaliana, phot1 and phot2. Phots, plant UVA/blue light photoreceptors, regulate growth responses and fast movements aimed at optimizing photosynthesis, such as phototropism, chloroplast relocations and stomatal ...
Justyna Łabuz +13 more
openaire +4 more sources
Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Frontiers in Plant Science, 2021 Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Souleimen Jmii, Laurent Cappadocia
doaj +1 more source
The impact of CRMP4 SUMOylation on the Cav1.2 interaction, neurite outgrowth and thermal pain sensitivity [PDF]
Journal of Integrative Neuroscience, 2021 Collapsin response mediator protein 4 (CRMP4) is critical for neuronal development. However, whether CRMP4 could be SUMOylated and how the SUMOylation regulates the interaction with the L-type voltage-gated calcium channel (Cav1.2), neurite outgrowth,
Shangdao Lai +5 more
doaj +1 more source
SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
Tak-Yu Yau +3 more
doaj +1 more source
SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]
PLoS ONE, 2017 BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk +4 more
doaj +1 more source
SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi. [PDF]
PLoS ONE, 2012 BACKGROUND: The flagellate protozoan parasite, Trypanosoma cruzi, is a causative agent of Chagas disease that is transmitted by reduviid bugs to humans. The parasite exists in multiple morphological forms in both vector and host, and cell differentiation
Takeshi Annoura +4 more
doaj +1 more source
Achieving Realistic Cyclist Behavior in SUMO using the SimRa Dataset [PDF]
Elsevier Computer Communications, vol. 205, pp. 97-107, May 2023, 2023 Increasing the modal share of bicycle traffic to reduce carbon emissions, reduce urban car traffic, and to improve the health of citizens, requires a shift away from car-centric city planning. For this, traffic planners often rely on simulation tools such as SUMO which allow them to study the effects of construction changes before implementing them ...
arxiv +1 more source