SUMO chain formation is required for response to replication arrest in S. pombe. [PDF]
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
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SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. [PDF]
PLoS ONE, 2014 Small ubiquitin-like modifier (SUMO) proteins regulate many important eukaryotic cellular processes through reversible covalent conjugation to target proteins.
Li-zhao Chen +12 more
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Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms [PDF]
Scientific Reports, 2023 Substantial increases in the conjugation of the main human SUMO paralogs, SUMO1, SUMO2, and SUMO3, are observed upon exposure to different cellular stressors, and such increases are considered important to facilitate cell survival to stress.
Myriah L. Acuña +11 more
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A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis [PDF]
, 2017 During Caenorhabditis elegans oocyte meiosis, a multi-protein ring complex (RC) localised between homologous chromosomes, promotes chromosome congression through the action of the chromokinesin KLP-19. While some RC components are known, the mechanism of
Gartner, Anton +5 more
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The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
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A SUMO interacting motif in the replication initiator protein of tomato yellow leaf curl virus is required for viral replication [PDF]
Journal of VirologyCircular Rep-encoding single-stranded (CRESS)-DNA viruses comprise a diverse group of viruses that use rolling-circle replication to copy their genomes. They infect organisms in almost all branches of the eukaryotic tree of life.
Nicolas Frédéric Gaertner +9 more
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Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Frontiers in Plant Science, 2021 Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Souleimen Jmii, Laurent Cappadocia
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SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
Tak-Yu Yau +3 more
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SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]
PLoS ONE, 2017 BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk +4 more
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SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi. [PDF]
PLoS ONE, 2012 BACKGROUND: The flagellate protozoan parasite, Trypanosoma cruzi, is a causative agent of Chagas disease that is transmitted by reduviid bugs to humans. The parasite exists in multiple morphological forms in both vector and host, and cell differentiation
Takeshi Annoura +4 more
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