SUMO chain formation is required for response to replication arrest in S. pombe. [PDF]
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
doaj +16 more sources
SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. [PDF]
PLoS ONE, 2014 Small ubiquitin-like modifier (SUMO) proteins regulate many important eukaryotic cellular processes through reversible covalent conjugation to target proteins.
Li-zhao Chen +12 more
doaj +5 more sources
Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms [PDF]
Scientific Reports, 2023 Substantial increases in the conjugation of the main human SUMO paralogs, SUMO1, SUMO2, and SUMO3, are observed upon exposure to different cellular stressors, and such increases are considered important to facilitate cell survival to stress.
Myriah L. Acuña +11 more
doaj +2 more sources
Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology [PDF]
, 2017 Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the development of therapeutics is an important task.
Adrian Whitehouse +24 more
core +3 more sources
Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Frontiers in Plant Science, 2021 Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Souleimen Jmii, Laurent Cappadocia
doaj +1 more source
SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
Tak-Yu Yau +3 more
doaj +1 more source
SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery. [PDF]
PLoS ONE, 2017 BACKGROUND:Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability.
Dora Baczyk +4 more
doaj +1 more source
SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi. [PDF]
PLoS ONE, 2012 BACKGROUND: The flagellate protozoan parasite, Trypanosoma cruzi, is a causative agent of Chagas disease that is transmitted by reduviid bugs to humans. The parasite exists in multiple morphological forms in both vector and host, and cell differentiation
Takeshi Annoura +4 more
doaj +1 more source
Enhanced in vitro refolding of fibroblast growth factor 15 with the assistance of SUMO fusion partner. [PDF]
PLoS ONE, 2011 Fibroblast growth factor 15 (Fgf15) is the mouse orthologue of human FGF19. Fgf15 is highly expressed in the ileum and functions as an endocrine signal to regulate liver function, including bile acid synthesis, hepatocyte proliferation and insulin ...
Bo Kong, Grace L Guo
doaj +1 more source
Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. [PDF]
PLoS ONE, 2012 The forkhead box protein A2 (FOXA2) is an important regulator of glucose and lipid metabolism and organismal energy balance. Little is known about how FOXA2 protein expression and activity are regulated by post-translational modifications.
Narasimhaswamy S Belaguli +3 more
doaj +1 more source