Results 91 to 100 of about 13,776 (215)

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease

Frontiers in Pharmacology, 2014
Alzheimer's disease (AD) is a complex disorder that affects the central nervous system causing a severe neurodegeneration. This pathology affects an increasing number of people worldwide due to the overall aging of the human population.
Robert eNisticò, Robert eNisticò, Caterina eFerraina, Veronica eMarconi, Fabio eBlandini, Lucia eNegri, Jan eEgebjerg, Marco eFeligioni   +7 more
doaj   +1 more source

Editorial: SUMO Proteins in Host Defense [PDF]

Frontiers in Cell and Developmental Biology, 2021
Carmen Rivas, Carmen Rivas
openaire   +4 more sources

The CTCF Insulator Protein Is Posttranslationally Modified by SUMO [PDF]

Molecular and Cellular Biology, 2009
The CTCF protein is a highly conserved zinc finger protein that is implicated in many aspects of gene regulation and nuclear organization. Its functions include the ability to act as a repressor of genes, including the c-myc oncogene. In this paper, we show that the CTCF protein can be posttranslationally modified by the small ubiquitin-like protein ...
Melissa J. MacPherson, Paul D. Sadowski, Wenjing Zhou, Linda G. Beatty, Minjie Du   +4 more
openaire   +2 more sources

Reshaping Protein‐Based Nanoparticles: Innovative Artificial Intelligence‐Driven Strategies for Structural Design and Applications

Advanced NanoBiomed Research, EarlyView.
Artificial Intelligence‐driven advancements in protein‐based nanoparticle design enable exceptional functionalities, overcoming traditional challenges and expanding nanomedicine applications. Nanoparticles (NPs) have become a pivotal technology in biomedical research due to their unique physicochemical properties and nanoscale size, allowing for ...
Mohammad Mahmoudi Gomari, Mehdi Alidadi, Neda Rostami, Sidi A. Bencherif   +3 more
wiley   +1 more source

SUMOylation of Warts kinase promotes neural stem cell reactivation

Nature Communications
A delicate balance between neural stem cell (NSC) quiescence and proliferation is important for adult neurogenesis and homeostasis. Small ubiquitin-related modifier (SUMO)-dependent post-translational modifications cause rapid and reversible changes in ...
Yang Gao, Ye Sing Tan, Jiaen Lin, Liang Yuh Chew, Htet Yamin Aung, Brinda Palliyana, Mahekta R. Gujar, Kun-Yang Lin, Shu Kondo, Hongyan Wang   +9 more
doaj   +1 more source

Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. [PDF]

PLoS Genetics, 2014
Post-translational modification of proteins by small ubiquitin-related modifier (SUMO) is reversible and highly evolutionarily conserved from yeasts to humans.
Jiang Fu, H-M Ivy Yu, Shang-Yi Chiu, Anthony J Mirando, Eri O Maruyama, Jr-Gang Cheng, Wei Hsu   +6 more
doaj   +1 more source

SUMO fusion technology for difficult-to-express proteins

Protein Expression and Purification, 2005
The demands of structural and functional genomics for large quantities of soluble, properly folded proteins in heterologous hosts have been aided by advancements in the field of protein production and purification. Escherichia coli, the preferred host for recombinant protein expression, presents many challenges which must be surmounted in order to over-
John Hall, Suzanne C. Edavettal, Michael R. Mattern, Tauseef R. Butt   +3 more
openaire   +3 more sources

Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

BioEssays, EarlyView.
UCHL1 is a neuron‐enriched component of the ubiquitin‐proteasome system. This review debates the biological relevance of its biochemical roles: limited DUB activity, potential ligase function, and mono‐ubiquitin stabilization. We emphasize the need to clarify the mechanisms and identify natural substrates for each function to understand their role in ...
Anwar Bdarneh, Inbal Maniv, Michael H. Glickman   +2 more
wiley   +1 more source

Small ubiquitin-like modifier-tag and modified protein purification significantly increase the quality and quantity of recombinant African swine fever virus p30 protein [PDF]

Veterinary World
Background and Aim: African swine fever (ASF) is a highly virulent and contagious viral disease caused by the ASF virus (ASFV). It has a significant impact on swine production throughout the world, while existing vaccines and specific treatments remain ...
Jullada Chootip, Payuda Hansoongnern, Nattarat Thangthamniyom, Sirin Theerawatanasirikul, Penpitcha Chankeeree, Challika Kaewborisuth, Porntippa Lekcharoensuk   +6 more
doaj   +1 more source

A tailored phospho‐p53 library probes antibody specificity and recognition limitations

ChemBioChem, Accepted Article.
The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) play a role in p53 activation, yet their precise mechanisms of action remain elusive due to challenges in ...
Mateusz Hess, Jonathan Davies, Sofia Margiola, Sonja Schneider, Thomas Hicks, Nishant Rai, Manuel Martin Müller   +6 more
wiley   +1 more source