Results 101 to 110 of about 13,776 (215)

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, Accepted Article.
The Ubiquitin‐like protein FUBI is encoded in humans by the FAU gene, whose down‐regulation in prostate, ovarian and breast cancer is significantly associated with poor prognosis. Despite its implications in disease progression, the regulatory mechanisms orchestrated by FUBI remain elusive. To address this knowledge gap, we developed a linear synthetic
Francesca D'Amico, Cami Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T.N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique Priscilla Catharina Mulder   +8 more
wiley   +1 more source

Exposure Experiments to Test the Kinetic Stability of 5‐Hydroxymethylfurfural Oxidase (HMFO) in Different Reactor Environments

ChemCatChem, EarlyView.
Scaling beyond the laboratory exposes enzymes to new stresses. Exposure experiments reveal that dynamic gas‐liquid interfaces introduced by sparging or air entrainment during agitation are the main drivers of HMFO deactivation. Replacing bubbles with a membrane‐based bubble‐free aeration system dramatically enhances stability. These experiments provide
Amalie Vang Høst, Moritz Meyer, Patrick Bongratz, Marco W. Fraaije, John M. Woodley   +4 more
wiley   +1 more source

Semantic Modeling with SUMO [PDF]

arXiv, 2020
We explore using the Suggested Upper Merged Ontology (SUMO) to develop a semantic simulation. We provide two proof-of-concept demonstrations modeling transitions in a simulated gasoline engine using a general-purpose programming language. Rather than focusing on computationally highly intensive techniques, we explore a less computationally intensive ...
arxiv  

Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling

Medicine Bulletin, EarlyView.
ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen, Qiao Cheng, Fang Gong, Hui Zheng   +3 more
wiley   +1 more source

Identification of SUMO conjugation sites in the budding yeast proteome

Microbial Cell, 2017
Post-translational modification by the small ubiquitin-like modifier (SUMO) is an important mechanism regulating protein function. Identification of SUMO conjugation sites on substrates is a challenging task.
Miguel Esteras, I-Chun Liu, Ambrosius P. Snijders, Adam Jarmuz, Luis Aragon   +4 more
doaj   +1 more source

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source

Validating WordNet Meronymy Relations using Adimen-SUMO [PDF]

arXiv, 2018
In this paper, we report on the practical application of a novel approach for validating the knowledge of WordNet using Adimen-SUMO. In particular, this paper focuses on cross-checking the WordNet meronymy relations against the knowledge encoded in Adimen-SUMO.
arxiv  

Distinct and Overlapping Sets of SUMO-1 and SUMO-2 Target Proteins Revealed by Quantitative Proteomics

Molecular & Cellular Proteomics, 2006
The small ubiquitin-like modifier (SUMO) family in vertebrates includes three different family members that are conjugated as post-translational modifications to target proteins. SUMO-2 and -3 are nearly identical but differ substantially from SUMO-1.
Vertegaal, Alfred C.O., Andersen, Jens S., Ogg, Stephen C., Hay, Ronald T., Mann, Matthias, Lamond, Angus I.   +5 more
openaire   +5 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

PLoS ONE, 2014
SUMO is a small post-translational modifier, that is attached to lysine residues in target proteins. It acts by altering protein-protein interactions, protein localisation and protein activity.
Jirapas Jongjitwimol, Min Feng, Lihong Zhou, Oliver Wilkinson, Lauren Small, Robert Baldock, Deborah L Taylor, Duncan Smith, Lucas D Bowler, Simon J Morley, Felicity Z Watts   +10 more
doaj   +1 more source