Results 111 to 120 of about 54,326 (298)

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]

, 2008
Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J., Elsasser, Suzanne, Finley, Daniel, Goh, Amanda M., Howley, Peter M., Verma, Rati, Walters, Kylie J.   +6 more
core   +6 more sources

Identification of SUMO conjugation sites in the budding yeast proteome

Microbial Cell, 2017
Post-translational modification by the small ubiquitin-like modifier (SUMO) is an important mechanism regulating protein function. Identification of SUMO conjugation sites on substrates is a challenging task.
Miguel Esteras, I-Chun Liu, Ambrosius P. Snijders, Adam Jarmuz, Luis Aragon   +4 more
doaj   +1 more source

MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]

, 2016
We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger, Orr, Anne, Sloan, Elizabeth   +2 more
core   +1 more source

Over‐Expression of a Phycocyanin‐Interferon Fusion and Differential Cleaving Efficiency in Cyanobacteria (Synechocystis sp. PCC 6803)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Recombinant protein expression in heterologous biological systems is an expanding field in synthetic biology. Photosynthetic organisms have the potential to provide an efficient low‐cost platform for recombinant protein production because they require minimal growth nutrients and are less susceptible to zoonotic and other contaminants ...
Bharat Kumar Majhi, Anastasios Melis
wiley   +1 more source

Metal-induced nanoscale clusterization initiates protein liquid-liquid phase separation

Cell Reports
Summary: Liquid-liquid phase separation (LLPS) of biomolecules is a crucial mechanism in regulating cellular functions through dynamic formation of membrane-less organelles.
Sijia Xiang, Zhuanghao Hou, Yu Wang, Yang Yang, Hongze Hu, Chang Yin, Guangming Huang, Kaiming Cao, Yangzhong Liu   +8 more
doaj   +1 more source

Structural modeling and functional analysis of the essential ribosomal processing protease Prp from Staphylococcus aureus [PDF]

, 2017
In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a
Christie, Gail E., Johnson, Adam L., Peterson, Darrell L., Wall, Erin A.   +3 more
core   +2 more sources

Chemical Methods for Peptide and Protein Backbone Cleavage

ChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez, Christian A. Olsen   +1 more
wiley   +1 more source

The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

PLoS ONE, 2014
SUMO is a small post-translational modifier, that is attached to lysine residues in target proteins. It acts by altering protein-protein interactions, protein localisation and protein activity.
Jirapas Jongjitwimol, Min Feng, Lihong Zhou, Oliver Wilkinson, Lauren Small, Robert Baldock, Deborah L Taylor, Duncan Smith, Lucas D Bowler, Simon J Morley, Felicity Z Watts   +10 more
doaj   +1 more source

Systems-Level Mapping of Cancer Testis Antigen 1b/a to Sarcoma Pathways Identifies Activated Ran Binding-2 E3 SUMO-Protein Ligase and Transducin-Like Enhancer Protein 1. [PDF]

Front Genet, 2022
Papanikolaou NA, Hytiroglou P, Pantelidou P, Papavassiliou AG, Old LL.   +4 more
europepmc   +1 more source