Results 121 to 130 of about 13,776 (215)

Protein Inference and Protein Quantification: Two Sides of the Same Coin [PDF]

arXiv, 2012
Motivation: In mass spectrometry-based shotgun proteomics, protein quantification and protein identification are two major computational problems. To quantify the protein abundance, a list of proteins must be firstly inferred from the sample. Then the relative or absolute protein abundance is estimated with quantification methods, such as spectral ...
arxiv  

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, EarlyView.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

Cell Reports, 2013
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications.
Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishtha, Barbara L. Apostol, Thomas Peter Nicholson, Katalin Illes, Ya-Zhen Zhu, Mary Dasso, Gillian P. Bates, Marian Difiglia, Beverly Davidson, Erich E. Wanker, J. Lawrence Marsh, Christopher D. Lima, Joan S. Steffan, Leslie M. Thompson   +23 more
doaj   +1 more source

Covalent Modification of the Werner's Syndrome Gene Product with the Ubiquitin-related Protein, SUMO-1 [PDF]

, 2000
Yoh-ichi Kawabe, Masayuki Seki, Takahiko Seki, Wen-Sheng Wang, Osamu Imamura, Yasuhiro Furuichi, Hisato Saitoh, Takemi Enomoto   +7 more
openalex   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

SUMO conjugation – a mechanistic view

Biomolecular Concepts, 2017
The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways.
Pichler Andrea, Fatouros Chronis, Lee Heekyoung, Eisenhardt Nathalie   +3 more
doaj   +1 more source

The vaccinia virus E3L protein interacts with SUMO-1 and ribosomal protein L23a in a yeast two hybrid assay. [PDF]

, 2000
Sarah C. Rogan, Shaun Heaphy
openalex   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Common Properties of Nuclear Body Protein SP100 and TIF1α Chromatin Factor: Role of SUMO Modification [PDF]

, 2001
Jacob-S. Seeler, Agnès Marchio, Régine Losson, Joana Desterro, Ronald T. Hay, Pierre Chambon, Anne Dejean   +6 more
openalex   +1 more source

The IQ67‐domain protein IQD1 regulates fruit shape through complex multiprotein interactions in pepper (Capsicum annuum L.)

Plant Biotechnology Journal, EarlyView.
Summary Natural genetic variation can be used to improve important crop agronomic traits, and understanding the genetic basis of natural variation in fruit shape can help breeders develop pepper varieties that meet market demand. In this study, we identified a QTL controlling fruit length–width ratio by conventional genetic mapping, encoding a ...
Lianzhen Mao, Yiyu Shen, Qingzhi Cui, Yu Huang, Xiang Zhang, Junheng Lv, Wujun Xing, Dan Zhang, Naying Fang, Daqing Chen, Zhuoxuan Wu, Peiru Li, Minghua Deng, Lijun Ou, Xuexiao Zou, Zhoubin Liu   +15 more
wiley   +1 more source