SUMO conjugation – a mechanistic view
Biomolecular Concepts, 2017 The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways.
Pichler Andrea +3 more
doaj +1 more source
Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression [PDF]
, 2013 Aarti D. Rohira +3 more
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The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle
The FEBS Journal, EarlyView.DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh +2 more
wiley +1 more source
Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation
The FEBS Journal, EarlyView.Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev +2 more
wiley +1 more source
Molecular Microbiology, EarlyView.Bacillus subtilis RNase HII corrects ribonucleotide errors and mismatched ribonucleotides, but not damaged ribonucleotides. Mismatched ribonucleotides would also serve as substrates for mismatch repair while damaged ribonucleotides would be addressed through base excision repair.
Julianna R. Cresti, Lyle A. Simmons
wiley +1 more source
Post-Translational Modifications of Kaposi’s Sarcoma-Associated Herpesvirus Regulatory Proteins – SUMO and KSHV [PDF]
, 2012 Mel Campbell, Yoshihiro Izumiya
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Molecular Oral Microbiology, EarlyView.Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin +6 more
wiley +1 more source
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). [PDF]
, 2017 Mathias Droescher +4 more
openalex +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Strigolactones (SLs) are root‐to‐shoot phytohormones that regulate tillering (branching) and root development. Sugar, as an essential energy substance and signalling molecule, plays a fundamental role in the growth and development of plants. However, the molecular mechanisms by which SL directly regulates sugar allocation to control tillering ...
Miao Feng +22 more
wiley +1 more source
Quantitative analysis of multi‐protein interactions using FRET: Application to the SUMO pathway [PDF]
, 2008 Sarah F. Martin +3 more
openalex +1 more source