Results 141 to 150 of about 13,776 (215)
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expression [PDF]
, 2003 Gergana Dobreva +2 more
openalex +1 more source
Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
, 2005 A large number of proteins have shown ability to bind to SUMO (Small Ubiquitin like Modifier) proteins through a short conserved motif called SIM (SUMO Interacting Motif). The work presented here shows that the different SUMO isoforms interact with the hydrophobic core of the SIM by forming an intermolecular b-sheet with the b2 strand of SUMO.
openaire +2 more sources
Oxidative Stress in Antigen Processing and Presentation
MedComm – Oncology, Volume 4, Issue 2, June 2025.Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang +9 more
wiley +1 more source
PIAS proteins promote SUMO-1 conjugation to STAT1 [PDF]
, 2003 Daniela Ungureanu +7 more
openalex +1 more source
Protein Science, Volume 34, Issue 6, June 2025.Abstract Transcription factors carry long intrinsically disordered regions often containing multiple activation domains. Despite numerous recent high‐throughput identifications and characterizations of activation domains, the interplay between sequence motifs, activation domains, and regulator binding in intrinsically disordered transcription factor ...
Amanda D. Due +10 more
wiley +1 more source
Arsenic and SUMO wrestling in protein modification [PDF]
Cell Cycle, 2017 Lingzhi Li, Fei Chen
openaire +3 more sources
Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1
Protein Science, Volume 34, Issue 6, June 2025.Abstract Apurinic/apyrimidinic endonuclease I (APE1) acts as both an endonuclease and a redox factor to ensure cell survival. The two activities require different conformations of APE1. As an endonuclease, APE1 is fully folded. As a redox factor, APE1 must be partially unfolded to expose the buried residue Cys65, which reduces transcription factors ...
Ratan Rai +7 more
wiley +1 more source
Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells
Journal of Biomedical ScienceSUMOylation, which is a type of post-translational modification that involves covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates various important molecular and cellular processes, including ...
Chien-Hsin Huang +2 more
doaj +1 more source