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Identification of SUMO–Protein Conjugates
2005Modification of proteins by covalent attachment of ubiquitin and the ubiquitin-like modifier SUMO are widespread regulatory events of all eukaryotic cells. SUMOylation has received much attention, because several identified targets play prominent roles, in particular, in cell signaling, gene expression, and DNA repair.
Boris Pfander +2 more
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Identification of SUMO Target Proteins by Quantitative Proteomics [PDF]
, 2009 The identification of target proteins for small ubiquitin-like modifiers (SUMOs) is a critical step towards a detailed understanding of the cellular functions of SUMOs. Substrate protein identification for SUMOs is hampered by the low abundance of SUMO targets, the finding that only a small fraction of these target proteins is sumoylated, and the high ...
Andersen, Jens S +2 more
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Enhanced SUMOylation of proteins containing a SUMO-interacting motif by SUMO-Ubc9 fusion
Biochemical and Biophysical Research Communications, 2009Identifying new targets for SUMO and understanding the function of protein SUMOylation are largely limited by low level of SUMOylation. It was found recently that Ubc9, the SUMO E2 conjugating enzyme, is covalently modified by SUMO at a lysine 14 in the N-terminal alpha helix, and that SUMO-modified Ubc9 has enhanced conjugation activity for certain ...
Eui Tae Kim +3 more
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Abstract B69: SUMO-binding proteins as effectors and regulators of SUMO modification
Cancer Research, 2009Abstract SUMOs (Small Ubiquitin-related Modifiers) are reversibly conjugated to other proteins in the cell, thereby regulating a wide range of essential functions. Many of the functions regulated by SUMOylation are intimately tied to processes directly relevant to cancer, including maintenance of genome integrity and cell cycle ...
Michael J. Matunis +5 more
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Protein Complexes in SUMO Signaling
2007SUMO is a small ubiquitin-related modifier implicated in control of various cellular processes including gene transcription, cell cycle, DNA repair and apoptosis. Here we describe details of the SUMO molecular machineries implicated in the formation of signaling networks that underlie the specificity in these biological processes.
Ivan Dikic, Christina-Maria Hecker
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SUMO modification regulates the protein stability of NDRG1
Biochemical and Biophysical Research Communications, 2015N-myc Downstream Regulated Gene 1 (NDRG1) is a metastasis suppressor protein which suppresses metastasis without affecting primary tumorigenesis. There have been many reports about the anti-metastatic function of NDRG1 in various cancers. However, the regulatory mechanism of NDRG1 at the protein level has not been studied widely.
Jae Eun Lee, Jung Hwa Kim
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PIAS proteins: pleiotropic interactors associated with SUMO
Cellular and Molecular Life Sciences, 2009The interactions and functions of protein inhibitors of activated STAT (PIAS) proteins are not restricted to the signal transducers and activators of transcription (STATs), but PIAS1, -2, -3 and -4 interact with and regulate a variety of distinct proteins, especially transcription factors. Although the majority of PIAS-interacting proteins are prone to
Tiina Jääskeläinen +4 more
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Total chemical synthesis of SUMO proteins
Tetrahedron Letters, 2016AbstractReview: 60 refs.
Oleg Melnyk, Jérôme Vicogne
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2009
The covalent modification of cellular factors by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory pathway for many biological processes. One recent advance in the field of SUMO modification that has provided important insights into SUMO-mediated regulatory networks is the ability to use proteomic mass spectrometry to identify ...
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The covalent modification of cellular factors by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory pathway for many biological processes. One recent advance in the field of SUMO modification that has provided important insights into SUMO-mediated regulatory networks is the ability to use proteomic mass spectrometry to identify ...
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