Results 21 to 30 of about 13,776 (215)

Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1

Frontiers in Cell and Developmental Biology, 2021
Viruses interact with the host cellular pathways to optimize cellular conditions for replication. The Human Cytomegalovirus (HCMV) Immediate-Early protein 1 (IE1) is the first viral protein to express during infection.
Vasvi Tripathi, Kiran Sankar Chatterjee, Ranabir Das   +2 more
doaj   +1 more source

Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins

Journal of Visualized Experiments, 2019
Here we are presenting a novel method to study the sumoylation of proteins and their sub-cellular localization in mammalian cells and nematode oocytes. This method utilizes a recombinant modified SUMO-trapping protein fragment, kmUTAG, derived from the Ulp1 SUMO protease of the stress-tolerant budding yeast Kluyveromyces marxianus.
Oliver Kerscher, Rui Yin, Catherine Harvey, Diane C. Shakes   +3 more
openaire   +4 more sources

Global SUMO proteome responses guide gene regulation, mRNA biogenesis, and plant stress responses

Frontiers in Plant Science, 2012
Small-ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on ...
Magdalena eMazur, Harrold Alfred Van Den Burg   +1 more
doaj   +1 more source

SUMO modification and its regulation of signaling pathways [PDF]

Jichu yixue yu linchuang, 2021
SUMO modification is a kind of post-translational modification of proteins, which plays an important role in regulating protein stability, protein-protein interaction and subcellular localization.
XIAO Yun-fei, WANG Jia-bin, GENG Hai-gang, LIU Qing-juan
doaj  

SUMO targeting of a stress-tolerant Ulp1 SUMO protease. [PDF]

PLoS ONE, 2018
SUMO proteases of the SENP/Ulp family are master regulators of both sumoylation and desumoylation and regulate SUMO homeostasis in eukaryotic cells. SUMO conjugates rapidly increase in response to cellular stress, including nutrient starvation, hypoxia ...
Jennifer Peek, Catherine Harvey, Dreux Gray, Danny Rosenberg, Likhitha Kolla, Reuben Levy-Myers, Rui Yin, Jonathan L McMurry, Oliver Kerscher   +8 more
doaj   +1 more source

SUMOylation in Drosophila Development

Biomolecules, 2012
Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins.
Albert J. Courey, Wiam Turki-Judeh, Matthew Smith   +2 more
doaj   +1 more source

Analysis of SUMOylated proteins using SUMO-traps [PDF]

Scientific Reports, 2013
SUMO-modified proteins are recognized by SUMO interacting motifs (SIMs), thus triggering diverse cellular responses. Here SIMs were used to develop SUMO-traps to capture endogenous SUMOylated proteins. Our results show that these small peptides are transferable motifs that maintain their SUMO binding capacity when fused to the heterologous carrier ...
Valérie Lang, Elisa Da Silva-Ferrada, Manuel S. Rodriguez, Carlos F. de la Cruz-Herrera, Fabienne Aillet, Itziar Martín-Ruiz, Carmen Rivas, Fernando Lopitz-Otsoa, Patrick England, Patrick England, Seth J. Goldenberg, Wendy Xolalpa, Arkaitz Carracedo, Arkaitz Carracedo   +13 more
openaire   +4 more sources

A survey on deep reinforcement learning architectures, applications and emerging trends

IET Communications, EarlyView., 2022
Abstract From a future perspective and with the current advancements in technology, deep reinforcement learning (DRL) is set to play an important role in several areas like transportation, automation, finance, medical and in many more fields with less human interaction.
Surjeet Balhara, Nishu Gupta, Ahmed Alkhayyat, Isha Bharti, Rami Q. Malik, Sarmad Nozad Mahmood, Firas Abedi   +6 more
wiley   +1 more source

Improving the Competency of First-Order Ontologies [PDF]

Proceedings of the 8th International Conference on Knowledge Capture (K-CAP 2015). Palisades, NY. 2015, 2015
We introduce a new framework to evaluate and improve first-order (FO) ontologies using automated theorem provers (ATPs) on the basis of competency questions (CQs). Our framework includes both the adaptation of a methodology for evaluating ontologies to the framework of first-order logic and a new set of non-trivial CQs designed to evaluate FO versions ...
arxiv   +1 more source

SUMO proteins in the cardiovascular system: friend or foe? [PDF]

Journal of Biomedical Science, 2020
AbstractPost-translational modifications (PTMs) are crucial for the adaptation of various signalling pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent addition of a small chemical functional group such as a phosphate group (phosphorylation), methyl group (methylation), or acetyl group (acetylation); lipids like ...
Prithviraj Manohar Vijaya Shetty, Ashraf Yusuf Rangrez, Norbert Frey   +2 more
openaire   +4 more sources