Results 21 to 30 of about 54,326 (298)
SUMO‐Mimicking Peptides Inhibiting Protein SUMOylation [PDF]
ChemBioChem, 2014 AbstractThe ubiquitin‐like protein SUMO is transferred through a core E1–E2 cascade composed of the SUMO‐activating enzyme (SAE) and Ubc9 to modify cellular proteins and transmit important biological signals. SAE primarily recognizes the C‐terminal tail of SUMO and catalyzes ATP condensation with the SUMO C‐terminal carboxylate to activate its transfer
Bo, Zhao +5 more
openaire +2 more sources
A Method for SUMO Modification of Proteins in vitro
Bio-Protocol, 2018 The Small Ubiquitin-related Modifier (SUMO) is a protein that is post-translationally added to and reversibly removed from other proteins in eukaryotic cells.
Christine Lee +3 more
doaj +1 more source
Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology [PDF]
, 2017 Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the development of therapeutics is an important task.
Adrian Whitehouse +24 more
core +2 more sources
SUMO-SIM interactions regulate the activity of RGSZ2 proteins. [PDF]
PLoS ONE, 2011 The RGSZ2 gene, a regulator of G protein signaling, has been implicated in cognition, Alzheimer's disease, panic disorder, schizophrenia and several human cancers.
Javier Garzón +6 more
doaj +1 more source
Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]
, 2015 The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Anne Seifert +4 more
core +3 more sources
Localization of SUMO-modified Proteins Using Fluorescent Sumo-trapping Proteins
Journal of Visualized Experiments, 2019 Here we are presenting a novel method to study the sumoylation of proteins and their sub-cellular localization in mammalian cells and nematode oocytes. This method utilizes a recombinant modified SUMO-trapping protein fragment, kmUTAG, derived from the Ulp1 SUMO protease of the stress-tolerant budding yeast Kluyveromyces marxianus.
Rui, Yin +3 more
openaire +3 more sources
Global SUMO proteome responses guide gene regulation, mRNA biogenesis, and plant stress responses
Frontiers in Plant Science, 2012 Small-ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on ...
Magdalena eMazur +1 more
doaj +1 more source
SUMO modification and its regulation of signaling pathways [PDF]
Jichu yixue yu linchuang, 2021 SUMO modification is a kind of post-translational modification of proteins, which plays an important role in regulating protein stability, protein-protein interaction and subcellular localization.
XIAO Yun-fei, WANG Jia-bin, GENG Hai-gang, LIU Qing-juan
doaj
Tomosyn interacts with the SUMO E3 ligase PIASγ. [PDF]
PLoS ONE, 2014 Protein modification by Small Ubiquitin-like MOdifier (SUMO) entities is involved in a number of neuronal functions, including synaptogenesis and synaptic plasticity. Tomosyn-1 (syntaxin-binding protein 5; STXPB5) binds to t-SNARE (Soluble NSF Attachment
Cornelia J Geerts +4 more
doaj +1 more source
SUMOylation in Drosophila Development
Biomolecules, 2012 Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins.
Albert J. Courey +2 more
doaj +1 more source