Results 41 to 50 of about 13,776 (215)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004 SUMO (small ubiquitin-related modifier) family proteins are not only structurally but also mechanistically related to ubiquitin in that they are posttranslationally attached to other proteins. As ubiquitin, SUMO is covalently linked to its substrates via amide (isopeptide) bonds formed between its C-terminal glycine residue and the epsilon-amino group ...
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A Proteomic Study of SUMO-2 Target Proteins [PDF]
Journal of Biological Chemistry, 2004 The SUMO family in vertebrates includes at least three distinct proteins (SUMO-1, -2, and -3) that are added as post-translational modifications to target proteins. A considerable number of SUMO-1 target proteins have been identified, but little is known about SUMO-2.
Vertegaal, Alfred C.O. +7 more
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Traffic Modeling with SUMO: a Tutorial [PDF]
arXiv, 2023 This paper presents a step-by-step guide to generating and simulating a traffic scenario using the open-source simulation tool SUMO. It introduces the common pipeline used to generate a synthetic traffic model for SUMO, how to import existing traffic data into a model to achieve accuracy in traffic simulation (that is, producing a traffic model which ...
arxiv
Regulation of the Ebola Virus VP24 Protein by SUMO [PDF]
Journal of Virology, 2019 The Ebola virus VP24 protein plays a critical role in escape of the virus from the host innate immune response. Therefore, deciphering the molecular mechanisms modulating VP24 activity may be useful to identify potential targets amenable to therapeutics.
Carmen Rivas +17 more
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A Photo-Crosslinking Approach to Identify Class II SUMO-1 Binders
Frontiers in Chemistry, 2022 The small ubiquitin-like modifier (SUMO) is involved in various cellular processes and mediates known non-covalent protein-protein interactions by three distinct binding surfaces, whose interactions are termed class I to class III.
Kira Brüninghoff +4 more
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The Computation of Cyclic Peptide with Prolin-Prolin Bond as Fusion Inhibitor of DENV Envelope Protein through Molecular Docking and Molecular Dynamics Simulation [PDF]
, 2015 A disease that caused by dengue virus (DENV) has become the major health problem of the world. Nowadays, no effective treatment is available to overcome the disease due to the level of dengue virus pathogeneses. A novel treatment method such as antiviral drug is highly necessary for coping with the dengue disease.
arxiv +1 more source
A Real-Time SUMO-Binding Assay for the Analysis of the SUMO-SIM Protein Interaction Network [PDF]
Bioscience, Biotechnology, and Biochemistry, 2010 SUMO-interacting motifs (SIMs) play a central role in the fate of SUMO-modified proteins. Here we report a real-time SUMO-binding assay. It can be applied to the identification of SIMs and to screening for the identification of novel SUMO-binding proteins.
Niina Tanaka, Hisato Saitoh
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SUMO-1 possesses DNA binding activity
BMC Research Notes, 2010 Background Conjugation of small ubiquitin-related modifiers (SUMOs) is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs).
Wieruszeski Jean-Michel +3 more
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QarSUMO: A Parallel, Congestion-optimized Traffic Simulator [PDF]
, 2020 Traffic simulators are important tools for tasks such as urban planning and transportation management. Microscopic simulators allow per-vehicle movement simulation, but require longer simulation time. The simulation overhead is exacerbated when there is traffic congestion and most vehicles move slowly.
arxiv +1 more source
Cellular Physiology and Biochemistry, 2017 Background: It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo.
Lifang Jin +4 more
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