Results 51 to 60 of about 54,326 (298)

Analysis of SUMOylated proteins using SUMO-traps [PDF]

Scientific Reports, 2013
SUMO-modified proteins are recognized by SUMO interacting motifs (SIMs), thus triggering diverse cellular responses. Here SIMs were used to develop SUMO-traps to capture endogenous SUMOylated proteins. Our results show that these small peptides are transferable motifs that maintain their SUMO binding capacity when fused to the heterologous carrier ...
da Silva-Ferrada, Elisa, Xolalpa, Wendy, Lang, Valérie, Aillet, Fabienne, Martin-Ruiz, Itziar, de La Cruz-Herrera, Carlos, Lopitz-Otsoa, Fernando, Carracedo, Arkaitz, Goldenberg, Seth, Rivas, Carmen, England, Patrick, Rodríguez, Manuel   +11 more
openaire   +3 more sources

SUMO-1 possesses DNA binding activity

BMC Research Notes, 2010
Background Conjugation of small ubiquitin-related modifiers (SUMOs) is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs).
Wieruszeski Jean-Michel, Smet-Nocca Caroline, Eilebrecht Sebastian, Benecke Arndt   +3 more
doaj   +1 more source

Function and regulation of ubiquitin-like SUMO system in heart

Frontiers in Cell and Developmental Biology, 2023
The small ubiquitin-related modifier (SUMOylation) system is a conserved, reversible, post-translational protein modification pathway covalently attached to the lysine residues of proteins in eukaryotic cells, and SUMOylation is catalyzed by SUMO ...
Ying Wang, Ying Wang, Zhihao Liu, Zhihao Liu, Xiyun Bian, Xiyun Bian, Chenxu Zhao, Xin Zhang, Xiaozhi Liu, Xiaozhi Liu, Nan Wang   +10 more
doaj   +1 more source

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David, Gill, Gomez-del Arco, Gostissa, Hong, I. Stancheva, Ichimura, Kirsh, Klose, Lin, Ling, Lyst, M.J. Lyst, Nathan, Nishida, Rodriguez, Shiio, Shin, Sterner, Uchimura, Verger, Yamaguchi, Yamamoto, Yang, Yang, Yang, Yang   +26 more
core   +1 more source

SUMO E3 ligase activity of TRIM proteins [PDF]

Oncogene, 2010
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an extremely limited number of small ubiquitin-like modifier (SUMO) protein ligases (E3s) have been identified.
Y, Chu, X, Yang
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities. [PDF]

Angew Chem Int Ed Engl
Non‐canonical glycopeptides of the proteoglycan linkage region are accessible by the enzymes B3GalT6 and GlcAT‐1 confirming a recently discovered rescue mode in glycosaminoglycan (GAG) biosynthesis. The crystal structure of B3GalT6 revealed a covalent dimer linked by a disulfide. Abstract We selected the N,O‐glycosylated proteoglycan bikunin as a model
Weidler S, Bundgaard O, Hessefort M, Rädisch M, Graf CGF, Lam K, Neubauer VJ, Eisenreich J, Köhler L, Moremen KW, Steentoft C, Clausen H, Huang TY, Hung SC, Steegborn C, Weyand M, Unverzagt C.   +16 more
europepmc   +3 more sources

Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

eLife, 2021
The chloroplast proteome contains thousands of different proteins that are encoded by the nuclear genome. These proteins are imported into the chloroplast via the action of the TOC translocase and associated downstream systems.
Samuel James Watson, Na Li, Yiting Ye, Feijie Wu, Qihua Ling, R Paul Jarvis   +5 more
doaj   +1 more source

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]

, 2018
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti, Abou-Sleiman, Adam-Vizi, Alexis A. Robinson, Ariga, Banerjee, Ben-Nissan, Blackinton, Boland, Bonifati, Bonifati, Brenner-Lavie, Campanella, Canet-Avilés, Cannon, Carlo Rodolfo, Caterina Ferraina, Chen, Daniela Strobbe, Dauer, Dias, Duchen, D’Autréaux, East, Gatliff, Georgakopoulos, Giaime, Giordano, Görner, Harvey, Hulleman, Junn, Kahle, Kim, Kirsten Harvey, Lakshminarasimhan, Lara Rossi, Lücking, Maita, Martinat, Martinez-Vicente, Matic, Michelangelo Campanella, Moscovitz, Muller, Murphy, Narendra, Niki, Olzmann, Ono, Onyango, Paisán-Ruíz, Pankratz, Parker, Parsanejad, Polymeropoulos, Robert J. Harvey, Schon, Shendelman, Shinbo, Taira, Takahashi, Takahashi-Niki, Valente, Valerio de Biase, Waak, Wang   +66 more
core   +3 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source