Results 51 to 60 of about 13,776 (215)

Function and regulation of ubiquitin-like SUMO system in heart

Frontiers in Cell and Developmental Biology, 2023
The small ubiquitin-related modifier (SUMOylation) system is a conserved, reversible, post-translational protein modification pathway covalently attached to the lysine residues of proteins in eukaryotic cells, and SUMOylation is catalyzed by SUMO ...
Ying Wang, Ying Wang, Zhihao Liu, Zhihao Liu, Xiyun Bian, Xiyun Bian, Chenxu Zhao, Xin Zhang, Xiaozhi Liu, Xiaozhi Liu, Nan Wang   +10 more
doaj   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

eLife, 2021
The chloroplast proteome contains thousands of different proteins that are encoded by the nuclear genome. These proteins are imported into the chloroplast via the action of the TOC translocase and associated downstream systems.
Samuel James Watson, Na Li, Yiting Ye, Feijie Wu, Qihua Ling, R Paul Jarvis   +5 more
doaj   +1 more source

Converting the Suggested Upper Merged Ontology to Typed First-order Form [PDF]

arXiv, 2023
We describe the translation of the Suggested Upper Merged Ontology (SUMO) to Typed First-order Form (TFF) with level 0 polymorphism. Building on our prior work to create a TPTP FOF translation of SUMO for use in the E and Vampire theorem provers, we detail the transformations required to handle an explicitly typed logic, and express SUMO's type ...
arxiv  

A WLM Protein with SUMO-Directed Protease Activity [PDF]

Molecular and Cellular Biology, 2010
Covalent modification of eukaryotic proteins by ubiquitin and the distantly related ubiquitin-like protein called SUMO contributes to an extraordinary assortment of biological regulatory mechanisms (2). These attachments have different consequences, depending not only on which of the proteins is attached but also on whether they are in the form of a ...
Dan Su, Mark Hochstrasser
openaire   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

The Role of the Small Ubiquitin-Related Modifier (SUMO) Pathway in Prostate Cancer

Biomolecules, 2012
SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events.
Christos N. Papandreou, Panagiotis J. Vlachostergios   +1 more
doaj   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Translating SUMO-K to Higher-Order Set Theory [PDF]

arXiv, 2023
We describe a translation from a fragment of SUMO (SUMO-K) into higher-order set theory. The translation provides a formal semantics for portions of SUMO which are beyond first-order and which have previously only had an informal interpretation. It also for the first time embeds a large common-sense ontology into a very secure interactive theorem ...
arxiv  

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source