Results 61 to 70 of about 13,776 (215)
Biomolecules, 2012 Post-translational modifications are able to regulate protein function and cellular processes in a rapid and reversible way. SUMOylation, the post-translational modification of proteins by the addition of SUMO, is a highly conserved process that seems to
Andrea S. Rópolo +4 more
doaj +1 more source
Scientific Reports, 2023 Substantial increases in the conjugation of the main human SUMO paralogs, SUMO1, SUMO2, and SUMO3, are observed upon exposure to different cellular stressors, and such increases are considered important to facilitate cell survival to stress.
Myriah L. Acuña +11 more
doaj +1 more source
Crosstalk Between SUMO and Ubiquitin-Like Proteins: Implication for Antiviral Defense
Frontiers in Cell and Developmental Biology, 2021 Interferon (IFN) is a crucial first line of defense against viral infection. This cytokine induces the expression of several IFN-Stimulated Genes (ISGs), some of which act as restriction factors.
Mounira K. Chelbi-Alix +2 more
doaj +1 more source
SUMO modulation of protein aggregation and degradation
AIMS Molecular Science, 2015 Small ubiquitin-like modifier (SUMO) conjugation and binding to target proteins regulate a wide variety of cellular pathways. The functional aspects of SUMOylation include changes in protein-protein interactions, intracellular trafficking as well as protein aggregation and degradation.
Feligioni M +5 more
openaire +3 more sources
Advanced Science, EarlyView.The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong +13 more
wiley +1 more source
SuMo: A Mutation Testing Strategy for Solidity Smart Contracts [PDF]
arXiv, 2021 Smart Contracts are software programs that are deployed and executed within a blockchain infrastructure. Due to their immutable nature, directly resulting from the specific characteristics of the deploying infrastructure, smart contracts must be thoroughly tested before their release.
arxiv
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
Advanced Science, EarlyView.Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee +3 more
wiley +1 more source
SUMO chain formation is required for response to replication arrest in S. pombe.
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
doaj +1 more source
SUMO Chains Rule on Chromatin Occupancy
Frontiers in Cell and Developmental Biology, 2020 The dynamic and reversible post-translational modification of proteins and protein complexes with the ubiquitin-related SUMO modifier regulates a wide variety of nuclear functions, such as transcription, replication and DNA repair.
Jan Keiten-Schmitz +2 more
doaj +1 more source
Advanced Science, EarlyView.In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang +8 more
wiley +1 more source