Results 71 to 80 of about 13,776 (215)
Using dot blot with immunochemical detection to evaluate global changes in SUMO-2/3 conjugation
BioTechniques, 2012 Small ubiquitin-related modifier-2/3 (SUMO-2/3) is a member of the ubiquitin-like (Ubl) protein family. Conjugation of SUMO-2/3 to target proteins is influenced by various stress conditions and chemical inhibitors.
Markéta Častorálová +2 more
doaj +1 more source
Regulation of Ebola virus VP40 matrix protein by SUMO [PDF]
Scientific Reports, 2016 AbstractThe matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and has an intrinsic ability to form virus-like particles. The elucidation of the regulation of VP40 functions is essential to identify mechanisms to inhibit viral ...
Manuel S. Rodriguez +14 more
openaire +4 more sources
HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
Advanced Science, EarlyView.Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim +9 more
wiley +1 more source
Traffic Reconstruction and Analysis of Natural Driving Behaviors at Unsignalized Intersections [PDF]
arXiv, 2023 This paper explores the intricacies of traffic behavior at unsignalized intersections through the lens of a novel dataset, combining manual video data labeling and advanced traffic simulation in SUMO. This research involved recording traffic at various unsignalized intersections in Memphis, TN, during different times of the day. After manually labeling
arxiv
Evaluating the Competency of a First-Order Ontology [PDF]
Proceedings of the 8th International Conference on Knowledge
Capture (K-CAP 2015). Palisades, NY. 2015, 2015 We report on the results of evaluating the competency of a first-order ontology for its use with automated theorem provers (ATPs). The evaluation follows the adaptation of the methodology based on competency questions (CQs) [Gr\"uninger&Fox,1995] to the framework of first-order logic, which is presented in [\'Alvez&Lucio&Rigau,2015], and is applied to ...
arxiv +1 more source
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
Molecular Characterization and Functional Localization of a Novel SUMOylation Gene in Oryza sativa
Biology, 2021 Small ubiquitin-related modifier (SUMO) regulates the cellular function of diverse proteins through post-translational modifications. The current study defined a new homolog of SUMO genes in the rice genome and named it OsSUMO7. Putative protein analysis
Eid I. Ibrahim +5 more
doaj +1 more source
Enhancing SUMO simulator for simulation based testing and validation of autonomous vehicles [PDF]
arXiv, 2021 Current autonomous vehicle (AV) simulators are built to provide large-scale testing required to prove capabilities under varied conditions in controlled, repeatable fashion. However, they have certain failings including the need for user expertise and complex inconvenient tutorials for customized scenario creation.
arxiv
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
A global S. cerevisiae small ubiquitin‐related modifier (SUMO) system interactome
Molecular Systems Biology, 2013 The small ubiquitin‐related modifier (SUMO) system has been implicated in a number of biological functions, yet the individual components of the SUMO machinery involved in each of these activities were largely unknown.
Tharan Srikumar +2 more
doaj +1 more source