Results 81 to 90 of about 13,776 (215)
SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation [PDF]
arXiv, 2004 Small Ubiquitin-related modifier (SUMO) proteins are widely expressed in eukaryotic cells, which are reversibly coupled to their substrates by motif recognition, called sumoylation. Two interesting questions are 1) how many potential SUMO substrates may be included in mammalian proteomes, such as human and mouse, 2) and given a SUMO substrate, can we ...
arxiv
A Novel Traffic Simulation Framework for Testing Autonomous Vehicles Using SUMO and CARLA [PDF]
arXiv, 2021 Traffic simulation is an efficient and cost-effective way to test Autonomous Vehicles (AVs) in a complex and dynamic environment. Numerous studies have been conducted for AV evaluation using traffic simulation over the past decades. However, the current simulation environments fall behind on two fronts -- the background vehicles (BVs) fail to simulate ...
arxiv
SUMO defeats protein aggregates
Journal of Cell Biology, 2011 ![Figure][1] Unsumoylated α-synuclein aggregates into fibrils (right), whereas sumoylated α-synuclein doesn't (left). Sumoylation might prevent the protein aggregations that typify Parkinson's disease (PD), [Krumova et al.][2] report.
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SUMO‐Mimicking Peptides Inhibiting Protein SUMOylation [PDF]
ChemBioChem, 2014 AbstractThe ubiquitin‐like protein SUMO is transferred through a core E1–E2 cascade composed of the SUMO‐activating enzyme (SAE) and Ubc9 to modify cellular proteins and transmit important biological signals. SAE primarily recognizes the C‐terminal tail of SUMO and catalyzes ATP condensation with the SUMO C‐terminal carboxylate to activate its transfer
Bo Zhao +5 more
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Advanced Science, EarlyView.The complex centered on Ghd7 binds to numerous carbon and nitrogen metabolism genes on the genome through the corresponding motifs and transactivates the transcriptional expression of these carbon and nitrogen metabolism genes. With the assistance of OsNAC42 and other unknown Ghd7‐interacting proteins, this complex can regulate different metabolic ...
Guangming Lou +23 more
wiley +1 more source
Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications
mBio, 2019 Regulation of a variety of different cellular processes, including posttranslational modifications, is critical for the ability of many viruses to replicate efficiently within host cells.
Sook-Young Sohn, Patrick Hearing
doaj +1 more source
PLoS Genetics, 2022 The sumoylation (SUMO) pathway is involved in a variety of processes during C. elegans development, such as gonadal and vulval fate specification, cell cycle progression and maintenance of chromosome structure.
Aleksandra Fergin +4 more
doaj +1 more source
A SUMO Framework for Deep Reinforcement Learning Experiments Solving Electric Vehicle Charging Dispatching Problem [PDF]
arXiv, 2022 In modern cities, the number of Electric vehicles (EV) is increasing rapidly for their low emission and better dynamic performance, leading to increasing demand for EV charging. However, due to the limited number of EV charging facilities, catering to the huge demand for time-consuming EV charging becomes a critical problem.
arxiv
SUMO E3 ligase activity of TRIM proteins [PDF]
Oncogene, 2010 SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an extremely limited number of small ubiquitin-like modifier (SUMO) protein ligases (E3s) have been identified.
Xiaolu Yang, Yaya Chu
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Advanced Science, EarlyView.Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu +7 more
wiley +1 more source