Results 71 to 80 of about 19,250 (186)

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

open access: yesCell Reports, 2012
Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the ...
Laure Crabbe   +4 more
doaj   +1 more source

Search for D to phi l nu and measurement of the branching fraction for D to phi pi

open access: yes, 2006
Using a data sample of integrated luminosity of about 33 pb$^{-1}$ collected around 3.773 GeV with the BESII detector at the BEPC collider, the semileptonic decays $D^+ \to \phi e ^+\nu_e$, $D^+ \to \phi \mu^+\nu_\mu$ and the hadronic decay $D^+ \to \phi
Ablikim, M.   +48 more
core   +1 more source

Decline in adaptive immune responses within human leptomeningesduring Alzheimer's Disease progression

open access: yesAlzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background The meninges comprise several layers of connective tissue that regulate the influx and efflux of fluid, protein, and immune cells to and from the brain parenchyma. However, it remains unclear how different cell types within the meninges contribute to the increasing dysfunction of this neurovascular‐immune interface during Alzheimer ...
Katherine M Sheu   +4 more
wiley   +1 more source

Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes

open access: yesCell Reports, 2015
Telomere-led rapid prophase movements (RPMs) in meiotic prophase have been observed in diverse eukaryote species. A shared feature of RPMs is that the force that drives the chromosomal movements is transmitted from the cytoskeleton, through the nuclear ...
Chih-Ying Lee   +7 more
doaj   +1 more source

Precision measurement of the $D^{*0}$ decay branching fractions

open access: yes, 2015
Using 482 pb$^{-1}$ of data taken at $\sqrt{s}=4.009$ GeV, we measure the branching fractions of the decays of $D^{*0}$ into $D^0\pi^0$ and $D^0\gamma$ to be $\BR(D^{*0} \to D^0\pi^0)=(65.5\pm 0.8\pm 0.5)%$ and $\BR(D^{*0} \to D^0\gamma)=(34.5\pm 0.8\pm ...
Ablikim, M.   +409 more
core   +1 more source

The NGF Metabolic Pathway is altered in a Rat Model of Human‐like Tauopathy

open access: yesAlzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Cholinergic signaling is crucial for learning, memory, and attention. In Alzheimer's disease (AD) the degeneration of basal forebrain cholinergic neurons (BFCNs) is a key pathological feature driven by an impaired maturation of nerve growth factor (NGF). Our lab identified the NGF metabolic pathway, which regulates mature NGF (mNGF)
Sonia Do Carmo   +6 more
wiley   +1 more source

SUN1 silencing inhibits cell growth through G0/G1 phase arrest in lung adenocarcinoma

open access: yesOncoTargets and Therapy, 2017
Cytoskeleton is critical for carcinoma cell proliferation, migration, and invasion. Sad-1 and UNC-84 domain containing 1 (SUN1) is one of the core linkers of nucleoskeleton and cytoskeleton. However, the functions of SUN1 in lung adenocarcinoma are largely unknown.In this study, we first transduced the lentivirus delivering the short hairpin RNA (shRNA)
Huang,Weiyi   +4 more
openaire   +4 more sources

Clinical and Neuroimaging Characteristics of Mild Cognitive Impairment Patients with Positive Central Nervous System Autoantibodies

open access: yesAlzheimer's &Dementia, Volume 21, Issue S3, December 2025.
Abstract Background Central nervous system autoantibodies have been identified in mild cognitive impairment (MCI) and dementia. This study firstly provides a comprehensive description of the clinical and neuroimaging characteristics of MCI with autoantibodies.
Heya Luan   +6 more
wiley   +1 more source

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response [PDF]

open access: yesCurrent Biology, 2012
The DNA damage response (DDR) and DNA repair are critical for maintaining genomic stability and evading many human diseases. Recent findings indicate that accumulation of SUN1, a nuclear envelope (NE) protein, is a significant pathogenic event in Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria syndrome, both caused by mutations in ...
Lei, Kai   +6 more
openaire   +2 more sources

First observation of $\psi(2S) \to p \bar{n} \pi^- +c.c.$

open access: yes, 2006
Using 14 million $\psi(2S)$ events collected with the Beijing Spectrometer (BESII) at the Beijing Electron-Positron Collider, the branching fractions of $\psi(2S)$ decays to $p \bar{n} \pi^-$ and $\bar{p} n \pi^+$ and the branching fractions of the main ...
B. A. Zhuang   +174 more
core   +1 more source

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