Results 231 to 240 of about 732,354 (302)

Dirac Surface‐State Driven Broad Spectral Band Low Quantum Energy Photoresponse in Quaternary Topological BiSbSe2Te

Advanced Science, EarlyView.
Quaternary topological BiSbSe2Te are synthesized and demonstrates a broad spectral band photoresponse, ranging from infrared to terahertz and to millimeter waves, with a particular excellence on detection of low quantum energy terahertz photons. The observed photoresponse is attributed to the excitation of plasmonic nonequilibrium electrons originating
Tianning Zhang, Jinchao Tong, Jiantian Zhang, Peng Yu, Heng Luo, Luo Yan, Boyu Yang, Tiantian Huang, Junhui Ran, Yan Chen, Liujiang Zhou, Xin Chen, Ning Dai, Jianlu Wang, Junhao Chu   +14 more
wiley   +1 more source

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Sun protection: a practical guide for health professionals. [PDF]

Aust Prescr
Morriss S, Scardamaglia L.
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Skin cancer awareness, attitude, and sun protection behavior among medical students in Saudi Arabia: A cross-sectional study. [PDF]

Medicine (Baltimore)
Bin Dayel S.
europepmc   +1 more source

Sun Exposure and Behaviours in Saudi Arabia: A National Study of over Eleven Thousand Participants Utilising the Arabic Sun Exposure and Behaviour Inventory. [PDF]

Healthcare (Basel)
Aleisa A, AbuDujain NM, Almuhaideb QA, Alrodiman YA, AlMajid HF, AboSarhad TN, Alali OA, Abudasir AM, Alkhudair D, Alshammari I, Veldhuizen IJ, Alsadhan KF, Alrasheed AA, Alsaad SM, Almigbal TH.   +14 more
europepmc   +1 more source

Regarding: "the impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer". [PDF]

Ann Med
Li D, Sun C, Wang C.
europepmc   +1 more source

Knowledge, attitudes and practices toward skin cancer prevention among Malaysian adults: a cross-sectional online survey. [PDF]

BMJ Open
Mohammed AH, Hassan BAR, Wong YJ, Ying LH, Hong MLB, Nee AWS, Ying LS, Ramachandram DS, Hassan HS, Jia LJ, Dujaili J, Blebil A.   +11 more
europepmc   +1 more source