Results 21 to 30 of about 1,305 (130)

Genetic Links Between Hydrogen Sulfide Pathways and Risk of Alzheimer's Disease and Related Risk Factors: A Phenome‐Wide Approach [PDF]

Alzheimers Dement
Abstract Background Hydrogen sulfide (H2S) is a promising therapeutic drug target for various pathologies, including Alzheimer's disease (AD) and related dementias (ADRD). The newly recognized gasotransmitter freely permeates cellular membranes and is vital to maintaining homeostasis, primarily via smooth muscle relaxation and vasodilatory mechanisms ...
Brady J, Reay W.
europepmc   +2 more sources

A comprehensive meta-analysis and prioritization study to identify vitiligo associated coding and non-coding SNV candidates using web-based bioinformatics tools

Scientific Reports, 2022
Vitiligo is a prevalent depigmentation disorder affecting around 1% of the general population. So far, various Genome Wide Association Studies (GWAS) and Candidate Gene Association Studies (CGAS) have identified several single nucleotide variants (SNVs ...
Tithi Dutta, Sayantan Mitra, Arpan Saha, Kausik Ganguly, Tushar Pyne, Mainak Sengupta   +5 more
doaj   +1 more source

A disease-modifying treatment for Alzheimer's disease : focus on the trans-sulfuration pathway

, 2020
High homocysteine levels in Alzheimer's disease (AD) result from low activity of the trans-sulfuration pathway. Glutathione levels are also low in AD. L-cysteine is required for the synthesis of glutathione.
Abohamza, Eid, Moustafa, Ahmed A. (R17078), Berry, Thomas L.   +2 more
core   +2 more sources

HYDROGEN SULFIDE SYSTEM ATTENUATES INJURY BY HYPERGLYCEMIA AND STRESS: ROLE OF MESENTERIC ADIPOCYTES IN AGED ANIMALS

Proceedings of the Shevchenko Scientific Society: Medical Sciences, 2018
Introduction. The mesentery is one of recently described separate organs which functions and its ability to protect injury are still unclear. Adipocytes are a part of mesentery (MAC), however, it is a little known about their age-related changes ...
Oleh Revenko, Natalia Zaichko, John Wallace, Oksana Zayachkivska   +3 more
doaj   +1 more source

Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing

Journal of Ovarian Research, 2022
Background Infertility is a global reproductive-health problem, and diminished ovarian reserve (DOR) is one of the common causes of female infertility.
Li Dong, Xin Xin, Hsun-Ming Chang, Peter C. K. Leung, Chen Yu, Fang Lian, Haicui Wu   +6 more
doaj   +1 more source

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.

PLoS Genetics, 2021
Discovering drugs that efficiently treat brain diseases has been challenging. Genetic variants that modulate the expression of potential drug targets can be utilized to assess the efficacy of therapeutic interventions.
Denis A Baird, Jimmy Z Liu, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt, AMP-AD eQTL working group   +22 more
doaj   +1 more source

Isolated Sulfite Oxidase Deficiency: Response to Dietary Treatment in a Patient with Severe Neonatal Presentation

Journal of Inborn Errors of Metabolism and Screening, 2019
Isolated sulfite oxidase deficiency (ISOD) is a devastating, neurometabolic disorder caused by mutations in the SUOX gene necessary for the final step in the sulfur-containing amino acid catabolic pathway.
Monica Boyer, Mary Sowa, Raymond Wang, Jose Abdenur   +3 more
doaj   +1 more source

Machine learning-based identification and characterization of 15 novel pathogenic SUOX missense mutations

, 2021
peer reviewedIsolated sulfite oxidase deficiency (ISOD) is a rare hereditary metabolic disease caused by absence of functional sulfite oxidase (SO) due to mutations of the SUOX gene.
Thaqi, Besarta, Schwarz, Guenter, MAY, Patrick, Bahlmann, Nike, Kaczmarek, Alexander Tobias, Alexander Tobias Kaczmarek, Patrick May, Besarta Thaqi, Guenter Schwarz, Nike Bahlmann   +9 more
core   +1 more source

Multimodal Integration of Genomic Data Reveals Regulatory Mechanisms at the Polycystic Ovary Syndrome (PCOS)-Associated 12q13.2 Locus. [PDF]

Int J Mol Sci
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting reproductive-aged women. Previous studies have identified genomic associations at chromosome 12q13.2, but the functional mechanisms underlying these associations remain unclear ...
Harris RA, McAllister JM, Strauss JF.
europepmc   +2 more sources

Hot Carriers and Photothermal Effects of Monolayer MoO_x for Promoting Sulfite Oxidase Mimetic Activity

, 2020
Local surface plasmon resonance (LSPR)-enhanced catalysis has brought a substantial amount of opportunities across various disciplines such as photocatalysis, photodetection, and photothermal therapeutics.
Yuan Chen (9740), Guowei Yang (163967), Xiaoju Wu (5077127), Tongming Chen (5077121)   +3 more
core   +1 more source