Results 41 to 50 of about 1,305 (130)

Mitochondria‐Related Pathogenic Genes in Paediatric Asthma: A Multi‐Omics Mendelian Randomization Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Biyu Zhang, Yaqin Li, Bo Ding, Xiaoyan Li, Yanming Lu   +4 more
wiley   +1 more source

The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia

, 2020
Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been ...
Thomas, Silke, Berh, Dimitri, Otto, Nils (Dr.), Schoofs, Andreas (Dr.), Bethke, Maria, Leimkühler, Silke (Prof. Dr.), Pankratz, Michael (Prof. Dr.), Jiang, Xiaoyi (Prof. Dr.), Marelja, Zvonimir (Dr.), Bittern, Jonas, Yildirim, Kerem (Dr.), Klämbt, Christian (Prof. Dr.), Kranenburg, Holger (Dr.), Rode, Sandra (Dr.), Risse, Benjamin   +14 more
core   +1 more source

Optimization of Microflow LC Coupled with Scanning SWATH and Its Application in Hepatocellular Carcinoma Tissues

Scanning SWATH coupled with normal-flow LC has been recently introduced for high-content, high-throughput proteomics analysis, which requires a relatively large amount of sample injection.
Jiang Zhu (40858), Vadim Demichev (5560499), Youqi Liu (12739513), Yi Zhu (105054), Markus Ralser (46782), Tiannan Guo (230314), Chen Chen (6544), Stephen Tate (1696342), Huanhuan Gao (382743), Cong Lu (428646)   +9 more
core   +5 more sources

Genomic measures of inbreeding coefficients and genome-wide scan for runs of homozygosity islands in Iranian river buffalo, Bubalus bubalis

BMC Genetics, 2020
Background Consecutive homozygous fragments of a genome inherited by offspring from a common ancestor are known as runs of homozygosity (ROH). ROH can be used to calculate genomic inbreeding and to identify genomic regions that are potentially under ...
Seyed Mohammad Ghoreishifar, Hossein Moradi-Shahrbabak, Mohammad Hossein Fallahi, Ali Jalil Sarghale, Mohammad Moradi-Shahrbabak, Rostam Abdollahi-Arpanahi, Majid Khansefid   +6 more
doaj   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Treatment-resistant schizophrenia : focus on the transsulfuration pathway

, 2020
Treatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. The severity of illness is positively related to homocysteine levels, with high homocysteine levels due to the low activity of the transsulfuration pathway, which metabolizes ...
Abohamza, Eid, Moustafa, Ahmed A. (R17078), Berry, Thomas L.   +2 more
core   +1 more source

Microspherophakia in a Case of Isolated Sulphite Oxidase Deficiency

TNOA Journal of Ophthalmic Science and Research
Isolated sulphite oxidase deficiency is an autosomal recessive hereditary disorder. A 5-month-old male child with neonatal seizures and global developmental delay was referred by a paediatrician for ophthalmological evaluation.
M Hemanandini, A Fathima Fahima
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Screening of a clinically and biochemically diagnosed SOD patient using exome sequencing: A case report with a mutations/variations analysis approach

Egyptian Journal of Medical Human Genetics, 2016
Background: Sulfite oxidase deficiency (SOD) is a rare neurometabolic inherited disorder causing severe delay in developmental stages and premature death.
Mohamad-Reza Aghanoori, Ghazaleh Mohammadzadeh Shahriary, Mahdi Safarpour, Ahmad Ebrahimi   +3 more
doaj   +1 more source