Results 61 to 70 of about 1,305 (130)

Abstract Fri086: CD38 NADase Suppresses Sulfite Oxidase (SUOX) and Activates Reverse Complex V to Promote Metabolic Remodeling in Endothelial Cells (ECs) Under Disturbed Flow

Introduction: Atherosclerotic lesions preferentially form in arterial regions exposed to disturbed flow (DF), where ECs exhibit mitochondrial (mt) dysfunction, metabolic reprogramming, and senescence.
gilbert mejia, Dale Hamilton, Rajneesh Pathania, Craig Morrell, Jonghae Lee, Kyung Ae Ko, Weiqing Chen, Guangyu Wang, Jared Burks, Paul Brookes, Junichi Abe, Masaki Imanishi, Kelia Ostos-Mendoza, Erin Seeley, Venkata Subrahman K Samanthapudi, JUNG HYUN KIM, Luis Antonio Rivera, Eduardo N Chini, Anita Deswal, James Martin, Ying Shen, Oanh Hoang, Aijun Zhang, NHAT TU LE, Sivareddy Kotla   +24 more
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Expression levels of differentially expressed mRNA transcripts.

, 2015
(A) Expression levels of differentially expressed mRNA transcripts between PCOS and controls in the LHCGR and RAB5B/SUOX loci. On the X axis are gene names. On the Y axis are the mean expression levels. Error bars represent standard deviation.
Meredith A. Brower (787278), Ricardo Azziz (198032), Mark O. Goodarzi (123440), Michelle R. Jones (179854), Jinrui Cui (420529), Ning Xu (52890), Emebet Mengesha (787279), Kent D. Taylor (123459), Yii-Der I. Chen (123464)   +8 more
core   +1 more source

Employing an ICT-FRET Integration Platform for the Real-Time Tracking of SO₂ Metabolism in Cancer Cells and Tumor Models

, 2020
Glutathione (GSH) mediates a wide variety of biological events and human diseases. Although it has been the subject of intense study in recent years, a further understanding of its molecular mechanisms and metabolism routes in living cells has remained ...
Fangjun Huo (3218874), Caixia Yin, Fangqin Cheng, Fangjun Huo, Weijie Zhang, Weijie Zhang (145595), Fangqin Cheng (601514), Caixia Yin (2426518)   +7 more
core   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia

, 2010
Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids. Decreased activity of this enzyme can either be due to mutations
GUNDUZ, Aysegul, Dantas Pinto, Kylvia Giselle, Rodrigues Funayama, Carolina Araujo, PINTO, Kylvia Giselle Dantas, Araujo Rodrigues Funayama, Carolina, Dos Santos, Leticia Yanasse, TASKIRAN, Emine, CAMELO JUNIOR, Jose Simon, TUYSUZ, Beyhan, LAM, Ching-Wan, SANTOS, Leticia Yanasse Dos, REISS, Jochen, FUNAYAMA, Carolina Araujo Rodrigues, TURCATO, Marlene de Fatima, Yanasse Dos Santos, Letícia, Sass, Jörn Oliver, KORKMAZ, Baris, SASS, Joern Oliver, YALCINKAYA, Cengiz, WALTER, Melanie, Fátima Turcato, Marlene de, De Fátima Turcato, Marlene, Saß, Jörn-Oliver, Baris Korkmaz, Beyhan Tuysuz, Yalcinkaya, C, José Simon Camelo Junior, Taskiran, E, Lam, CW, Aysegul Gunduz, Dantas Pinto, KG, Walter, M, Carolina Araujo Rodrigues Funayama, Cengiz Yalcinkaya, Marlene de Fátima Turcato, Jörn Oliver Sass, Gunduz, A, Melanie Walter, de Fátima Turcato, M, Ching-Wan Lam, Kylvia Giselle Dantas Pinto, Jochen Reiss, Sass, JO, Letícia Yanasse Dos Santos, Korkmaz, B, Araujo Rodrigues Funayama, C, Reiss, J, Camelo Junior, JS, Emine Taskiran, Tuysuz, B, Yanasse Dos Santos, L   +50 more
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DIE ARBEIT DES ÜBERSETZENS: RILKE UND MICHELANGELO („SE ’L MIE ROZZO MARTELLO‘‘)

German Life and Letters, Volume 78, Issue 2, Page 194-216, April 2025.
ABSTRACT This essay examines Rainer Maria Rilke's reception of the sculptor and poet Michelangelo in the context of interest in the Renaissance around 1900, focusing first on the Stundenbuch, the Florenzer Tagebuch and the story ʻVon einem, der die Steine belauschtʼ (from the prose collection: Geschichten vom lieben Gott).
Astrid Dröse, Jörg Robert
wiley   +1 more source

Exploring the causal relationship between gut microbiota and multiple myeloma risk based on Mendelian randomization and biological annotation

Frontiers in Microbiology
IntroductionThe microbial genome-wide association studies (mbGWAS) have highlighted significant host-microbiome interactions based on microbiome heritability.
Zuxi Feng, Minjing Liao, Jun Bai, Yanhong Li, Yue Chen, Li Zhang, Xuege Guo, Lijuan Li, Liansheng Zhang   +8 more
doaj   +1 more source

Assessment of urinary 6‐oxo‐pipecolic acid as a biomarker for ALDH7A1 deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
Abstract ALDH7A1 deficiency is an epileptic encephalopathy whose seizures respond to treatment with supraphysiological doses of pyridoxine. It arises as a result of damaging variants in ALDH7A1, a gene in the lysine catabolism pathway. α‐Aminoadipic semialdehyde (α‐AASA) and Δ1‐piperideine‐6‐carboxylate (P6C), which accumulate because of the block in ...
Youssef Khalil, Emma Footitt, Reddy Vootukuri, Michael F. Wempe, Curtis R. Coughlin II, Spyros Batzios, Matthew P. Wilson, Viktor Kožich, Peter T. Clayton, Philippa B. Mills   +9 more
wiley   +1 more source

Cross-Ethnic meta-Analysis of genetic variants for polycystic ovary syndrome

, 2013
Context: Genome-wide association studies (GWAS) have revealed new susceptibility loci for Chinese patients with polycystic ovary syndrome (PCOS). Because ethnic background adds to phenotypic diversities in PCOS, it seems plausible that genetic variants ...
Louwers, Y.V. (Yvonne), Stolk, L. (Lisette), Laven, J.S.E. (Joop), Uitterlinden, André; id_orcid, Laven, Joop, Uitterlinden, A.G. (André), Stolk, Lisette, Louwers, Yvonne; id_orcid   +7 more
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Negation in Sakha(Yakut) [PDF]

サハ語の文は，大きく動詞述語文と名詞述語文に分かれる．動詞述語文の否定は，大半の場合に動詞語幹に否定接辞を付加することで形成され，対応の肯定文とsymmetricalな構造を示す．動詞述語文で否定語suox「ない」あるいはilik「まだ」を含む分析的形式が用いられるのは，直説法未来などの一部のケースに限られている．名詞述語文の否定には3種類がある．存在否定文では，suox「ない」を述語として用いる．コピュラ否定文では，動詞buol「なる」の結果過去形を述語とする分析的形式が現れる．所有否定文では ...
江畑, 冬生, Ebata, Fuyuki
core   +1 more source