Results 171 to 180 of about 5,026 (202)

suPAR in Cardiovascular Disease

Advances in Clinical Chemistry
Soluble urokinase plasminogen activator receptor (suPAR), the soluble counterpart of urokinase plasminogen activator receptor, is found in the circulation at various levels. suPAR and its parent molecule, cell surface uPAR, exhibit similar structure and extracellular functional roles facilitating fibrinolysis, cellular adhesion, and migration.
Janice Chew-Harris
exaly   +3 more sources

A suPAR Biomarker for Chronic Kidney Disease

New England Journal of Medicine, 2015
The worldwide epidemic of chronic kidney disease — an insidious illness that manifests with asymptomatic reductions in the estimated glomerular filtration rate (eGFR) to less than 60 ml per minute per 1.73 m2 of body-surface area, excessive urinary excretion of protein, or both — afflicts an estimated 600 million people.1 Many will have progression to ...
Karl L, Skorecki, Barry I, Freedman
openaire   +2 more sources

Circulating suPAR Levels Are Affected by Glomerular Filtration Rate and Proteinuria in Primary and Secondary Glomerulonephritis

Journal of Nephrology, 2015
Circulating levels of soluble urokinase-like plasminogen activator receptor (suPAR) have been associated with proteinuria and renal function in focal segmental glomerulosclerosis (FSGS).
Sara Monti, Corrado Magnani, Umberto Dianzani   +2 more
exaly   +2 more sources

TREM-1 et suPAR

2012
La reconnaissance precoce des patients septiques les plus a risque permet une prise en charge adaptee dans les plus brefs delais, seule garante d’une amelioration du pronostic, tandis que la reconnaissance des malades les moins severes permet de limiter les temps de sejour aux urgences, et de prioriser les ressources.
D. Barraud, S. Gibot
openaire   +1 more source

suPAR and Chronic Kidney Disease—A Podocyte Story

Pflugers Archiv European Journal of Physiology, 2017
The soluble urokinase-type plasminogen activator receptor (suPAR) is a circulating signaling molecule derived from immature myeloid cells. Elevated levels of suPAR have been linked to the pathogenesis of the kidney disease focal and segmental glomerulosclerosis. Here, suPAR acts on podocytes by activating αvβ3 integrins.
Vasil Peev, Jochen Reiser, Martin Zeier
exaly   +3 more sources

An ELISA Method Detecting the Active Form of suPAR

Talanta, 2016
Urokinase plasminogen activator receptor (uPAR) exists in a number of formats in human plasma, including soluble uPAR (suPAR) and uPAR fragments. We developed an ELISA method to detect specifically the active form suPAR, which binds to its natural ligand uPA. The intra CV and inter CV of this ELISA assay is 8.5% and 9.6% respectively, and the assay can
Zafar Iqbal, Cai Yuan, Jincan Chen
exaly   +3 more sources

The Role of suPAR in Kidney Injury Progression

Current Molecular Medicine
Introduction: This article provides a thorough review of how suPAR influences kidney injury. It aims to inform relevant fields, clarify the mechanisms of its effects, and ultimately enhance patient treatment outcomes and quality of life. Methods:
Hong, Guo, Jincai, Yang, Qiaoyun, Ye, Luyi, Xiang, Feifei, Zhang, Jian, Liu   +5 more
openaire   +2 more sources

PP071. suPAR levels in normal- and preeclamptic pregnancies

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2013
Preeclampsia (PE) has been considered to be a maternal inflammatory response to pregnancy and may be hazardous for mother and child. Soluble urokinase Plasminogen Activator receptor (suPAR) is a non-specific marker that reflects overall systemic inflammation and immune activation.We examined the levels of suPAR in first and third trimesters of normal ...
Nancy, Odden, M C P, Roland, B, Lorentzen, L, Mørkrid, T, Henriksen   +4 more
openaire   +2 more sources

suPAR as a biomarker of support in different clinical settings

Clinica Chimica Acta
The urokinase-type plasminogen activator receptor (uPAR) system, which includes protease, receptor and inhibitors, is essential for key cellular functions like immune activation, cell migration, and tissue remodeling. Soluble uPAR (suPAR), released into circulation, serves as a valuable biomarker for systemic inflammation and immune activation ...
Fabio, Belvederi, Simone, Leggeri, Andrea, Urbani, Silvia, Baroni   +3 more
openaire   +2 more sources

suPAR and FSGS

Transplantation, 2013
Maarten, Naesens, Björn, Meijers, Ben, Sprangers   +2 more
openaire   +2 more sources